一种触发式 DNA 水凝胶覆盖物，用于包裹和释放单个细胞。
A triggered DNA hydrogel cover to envelop and release single cells.
机构信息
Key Laboratory of Organic Optoelectrics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China, Fax: +86-10-62796082; National Center for Nanoscience and Technology, Beijing 100190, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
出版信息
Adv Mater. 2013 Sep 14;25(34):4714-7. doi: 10.1002/adma.201301175. Epub 2013 Jul 9.
We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.
我们开发了一种酶触发的可渗透 DNA 水凝胶覆盖物，用于包裹和释放微井中的单个细胞。DNA 水凝胶的多孔结构允许营养物质和废物通过，从而使细胞活力高达 98%。该设计为培养、监测和操作单个细胞提供了一种通用方法，并在细胞图案化和研究细胞通讯方面具有潜在应用。
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