Jiang Yao, Krishnan Nishta, Heo Jiyoung, Fang Ronnie H, Zhang Liangfang
Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
J Control Release. 2020 Aug 10;324:505-521. doi: 10.1016/j.jconrel.2020.05.041. Epub 2020 May 26.
The incorporation of nanoparticles into hydrogels yields novel superstructures that have become increasingly popular in biomedical research. Each component of these nanoparticle-hydrogel superstructures can be easily modified, resulting in platforms that are highly tunable and inherently multifunctional. The advantages of the nanoparticle and hydrogel constituents can be synergistically combined, enabling these superstructures to excel in scenarios where employing each component separately may have suboptimal outcomes. In this review, the synthesis and fabrication of different nanoparticle-hydrogel superstructures are discussed, followed by an overview of their use in a range of applications, including drug delivery, detoxification, immune modulation, and tissue engineering. Overall, these platforms hold significant clinical potential, and it is envisioned that future development along these lines will lead to unique solutions for addressing areas of pressing medical need.
将纳米颗粒掺入水凝胶中可产生新型超结构，这些超结构在生物医学研究中越来越受欢迎。这些纳米颗粒-水凝胶超结构的每个组分都可以轻松修饰，从而产生高度可调且本质上具有多功能的平台。纳米颗粒和水凝胶成分的优势可以协同结合，使这些超结构在单独使用每个组分可能效果欠佳的情况下表现出色。在本综述中，我们讨论了不同纳米颗粒-水凝胶超结构的合成与制备，随后概述了它们在一系列应用中的用途，包括药物递送、解毒、免疫调节和组织工程。总体而言，这些平台具有巨大的临床潜力，预计沿着这些方向的未来发展将为解决迫切的医疗需求领域带来独特的解决方案。
