Kang Yun Kyung, Jin So-Young, Chang Mee Soo, Kim Jung Yeon, Kang Gyeong Hoon, Lee Hye Seung, Sohn Jin Hee, Park Ho Sung, Kwon Kye Won, Gu Mi Jin, Maeng Young Hee, Joo Jong Eun, Kang Haeng Ji, Kim Hee Kyung, Jang Kee-Taek, Lee Mi Ja, Chang Hee Kyung, Kim Joon Mee, Han Hye Seung, Lee Won Ae, Choi Yoon Jung, Kang Dong Wook, Park Sunhoo, Lee Jae Hyuk, Cho Mee-Yon
Korean J Pathol. 2013 Jun;47(3):245-51. doi: 10.4132/KoreanJPathol.2013.47.3.245. Epub 2013 Jun 25.
The incidence of early colorectal epithelial neoplasm (ECEN) is increasing, and its pathologic diagnosis is important for patient care. We investigated the incidence of ECEN and the current status of its pathologic diagnosis.
We collected datasheets from 25 institutes in Korea for the incidence of colorectal adenoma with high grade dysplasia (HGD) and low grade dysplasia in years 2005, 2007, and 2009; and early colorectal carcinoma in the year 2009. We also surveyed the diagnostic terminology of ECEN currently used by the participating pathologists.
The average percentage of diagnoses of adenoma HGD was 7.0%, 5.0%, and 3.4% in years 2005, 2007, and 2009, respectively. The range of incidence rates of adenoma HGD across the participating institutes has gradually narrowed over the years 2005 to 2009. The incidence rate of early colorectal carcinoma in the year 2009 was 21.2%. The participants did not share a single criterion or terminology for the diagnosis of adenoma HGD. The majority accepted the diagnostic terms that distinguished noninvasive, mucosal confined, and submucosal invasive carcinoma.
Further research requirements suggested are a diagnostic consensus for the histopathologic diagnosis of ECEN; and standardization of diagnostic terminology critical for determining the disease code.
早期结直肠上皮性肿瘤(ECEN)的发病率正在上升,其病理诊断对患者治疗至关重要。我们调查了ECEN的发病率及其病理诊断的现状。
我们收集了韩国25家机构2005年、2007年和2009年结直肠高级别异型增生腺瘤(HGD)和低级别异型增生腺瘤的发病率数据,以及2009年早期结直肠癌的发病率数据。我们还调查了参与研究的病理学家目前使用的ECEN诊断术语。
2005年、2007年和2009年腺瘤HGD的诊断平均百分比分别为7.0%、5.0%和3.4%。2005年至2009年期间,参与研究机构的腺瘤HGD发病率范围逐渐缩小。2009年早期结直肠癌的发病率为21.2%。参与者在腺瘤HGD的诊断上没有统一的标准或术语。大多数人接受区分非侵袭性、黏膜局限型和黏膜下侵袭性癌的诊断术语。
建议进一步开展的研究包括对ECEN的组织病理学诊断达成诊断共识;以及对确定疾病编码至关重要的诊断术语进行标准化。