Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
ACS Nano. 2013 Jul 23;7(7):5654-9. doi: 10.1021/nn403220e. Epub 2013 Jul 9.
Encapsulation of the platinum(IV) prodrug mitaplatin in block copolymer nanoparticles increases drug circulation time in the blood and reduces accumulation in the kidneys, as reported by Lippard and colleagues in this issue of ACS Nano. Importantly, controlled drug release from the nanoparticles produces long-term anticancer efficacy, with the prospect of reduced side effects. We highlight the potential that such a strategy holds for the future development of metallodrugs. Metal coordination complexes offer the prospect of novel mechanisms of activity on account of their unique architectures, as well as potential activation mechanisms, including ligand substitution and metal- and ligand-centered redox properties. Nanoparticles offer exciting prospects for improving delivery, cell uptake, and targeting of metallodrugs, especially anticancer drugs, to make them more effective and safer.
利帕德和同事在 ACS Nano 本期发表的文章中报告，将顺铂前药米他铂封装在嵌段共聚物纳米粒子中，可增加药物在血液中的循环时间，并减少在肾脏中的积累。重要的是，纳米粒子控制药物释放可产生长期的抗癌疗效，有望减少副作用。我们强调了这种策略在未来金属药物开发中的潜力。金属配合物具有独特的结构，提供了新颖的活性机制的前景，同时还具有潜在的激活机制，包括配体取代和金属及配体中心的氧化还原性质。纳米粒子为改善金属药物（尤其是抗癌药物）的递送、细胞摄取和靶向性提供了令人兴奋的前景，使它们更有效和更安全。
