Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Trends Endocrinol Metab. 2013 Oct;24(10):515-24. doi: 10.1016/j.tem.2013.05.008. Epub 2013 Jul 6.
Steroid hormone receptors (SHRs) are hormone-activated transcription factors involved in numerous cellular functions and in health and disease. Their activities depend on the cellular level of the receptor, the presence of coregulator proteins, and the cell signaling pathways that are active in the cell. SHRs and their coregulators are phosphorylated on multiple sites by a wide variety of kinases. Each site may contribute to multiple functions and the net effect of an individual phosphorylation depends on the activating kinase. Here we discuss functions of known SHR phosphorylation sites, kinase regulation, evidence of translational relevance, and crosstalk between SHRs and cell signaling pathways. Understanding how cell signaling pathways regulate SHRs might yield novel therapeutic targets for multiple human diseases.
甾体激素受体 (SHRs) 是激素激活的转录因子，参与多种细胞功能以及健康和疾病。它们的活性取决于受体在细胞中的水平、共激活蛋白的存在以及细胞信号通路的活性。SHR 及其共激活蛋白可被多种激酶在多个位点磷酸化。每个位点可能对多种功能有贡献，并且单个磷酸化的净效应取决于激活激酶。在这里，我们讨论了已知的 SHR 磷酸化位点的功能、激酶调节、翻译相关性的证据以及 SHR 与细胞信号通路之间的串扰。了解细胞信号通路如何调节 SHR 可能为多种人类疾病提供新的治疗靶点。
