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通过使用封端介孔纳米粒子增强药物的疗效和扩大抗菌作用。

Enhanced efficacy and broadening of antibacterial action of drugs via the use of capped mesoporous nanoparticles.

机构信息

Centro de Reconocimiento Molecular y Desarrollo Tecnológico, Departamento de Química, Universidad Politécnica de Valencia, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain.

出版信息

Chemistry. 2013 Aug 19;19(34):11167-71. doi: 10.1002/chem.201302170. Epub 2013 Jul 9.

DOI:10.1002/chem.201302170
PMID:23839913
Abstract

Bug busters: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε-poly-L-lysine (ε-PL) was prepared and its interaction with different Gram-negative bacteria studied. A remarkable improvement in the efficacy of the antimicrobial drug ε-PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.

摘要

灭菌利器

本研究制备了一种新型介孔纳米颗粒载药装置，该装置由载有万古霉素的介孔纳米颗粒和 ε-聚赖氨酸（ε-PL）组成，并研究了其与不同革兰氏阴性菌的相互作用。实验结果表明，ε-PL 的抗菌药物疗效显著提高，万古霉素的抗菌谱也得以拓宽。

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