Brown H R
Experimental Pathology Laboratories, Inc., Research Triangle Park, NC 27709.
Environ Health Perspect. 1990 Apr;85:291-304. doi: 10.1289/ehp.85-1568348.
The National Toxicology Program (NTP) database was examined for tumor incidences and chemicals producing tumors in the nasal cavity, larynx, or trachea. Slides from appropriate studies were then examined in an attempt to unify terminology and make comparisons between induced and spontaneous tumors and hyperplastic or preneoplastic lesions produced in the upper respiratory system. An attempt was also made to compare the species affected, route of administration, and tumor types produced by different chemicals. The results are not meant to be all inclusive of the NTP database but to be representative of observed trends. General conclusions that emerged from this review were that rats are much more susceptible to epithelial tumors of the nasal cavity than mice; that only mice have been reported to have chemically induced hemangiomas and hemangiosarcomas of the nasal cavity; that tumors of the olfactory epithelium and squamous cell tumors of the respiratory epithelium are almost uniformly malignant and invasive, while other tumors of the respiratory epithelium are typically less invasive; that most chemically induced tumors of the olfactory region, either mesenchymal or epithelial, do not require an inhalation route of exposure but appear to occur by systemic targeting of this region; and that a uniform nomenclature for tumors of the nasal cavity is needed.
对国家毒理学计划（NTP）数据库进行了检查，以了解鼻腔、喉或气管的肿瘤发生率以及产生肿瘤的化学物质。然后检查了适当研究的切片，试图统一术语，并比较上呼吸道诱发肿瘤与自发肿瘤以及增生性或癌前病变。还尝试比较受影响的物种、给药途径以及不同化学物质产生的肿瘤类型。结果并非涵盖NTP数据库的所有内容，而是代表观察到的趋势。此次综述得出的一般结论是，大鼠比小鼠更容易患鼻腔上皮肿瘤；据报道，只有小鼠有化学诱导的鼻腔血管瘤和血管肉瘤；嗅觉上皮肿瘤和呼吸上皮鳞状细胞肿瘤几乎均为恶性且具有侵袭性，而呼吸上皮的其他肿瘤通常侵袭性较小；大多数化学诱导的嗅觉区域肿瘤，无论是间充质肿瘤还是上皮肿瘤，都不需要吸入暴露途径，而是似乎通过该区域的全身靶向作用发生；并且需要统一鼻腔肿瘤的命名法。
