Depaulis A, Liu Z, Vergnes M, Marescaux C, Micheletti G, Warter J M
Département de Neurophysiologie et Biologie des Comportements, U.44 INSERM/Centre de Neurochimie du CNRS, Strasbourg, France.
Epilepsy Res. 1990 Apr;5(3):192-8. doi: 10.1016/0920-1211(90)90038-w.
Intranigral injections of GABA agonists suppress spontaneous and chemically induced generalized non-convulsive seizures in the rat. In order to examine whether the GABAergic nigrotectal pathway could be involved in this suppression, bilateral injections of GABA antagonists were performed in the superior colliculus of rats with spontaneous generalized non-convulsive seizures. Bilateral microinjections into this structure of the GABA antagonists picrotoxin (20 and 40 ng/side) and bicuculline methiodide (5 ng/side) suppressed spike-and-wave discharges for 40 min and 20 min post injection, respectively. Unilateral injections of picrotoxin (40 ng) into the superior colliculus as well as bilateral injections of a GABA agonist (muscimol; 80 ng) did not induce significant modifications. These results show that blockade of the GABAergic transmission at the level of the superior colliculus results in a suppression of generalized non-convulsive seizures. These data support the hypothesis that the suppressive effect of intranigral injections of GABA agonists over generalized non-convulsive seizures involves, at least in part, the nigrotectal GABAergic pathway.
向大鼠黑质内注射GABA激动剂可抑制自发性和化学诱导的全身性非惊厥性癫痫发作。为了研究GABA能黑质顶盖通路是否参与这种抑制作用，对患有自发性全身性非惊厥性癫痫发作的大鼠在上丘进行双侧GABA拮抗剂注射。向该结构双侧微量注射GABA拮抗剂印防己毒素（每侧20和40纳克）和甲碘化荷包牡丹碱（每侧5纳克），分别在注射后40分钟和20分钟抑制棘波和慢波放电。向上丘单侧注射印防己毒素（40纳克）以及双侧注射GABA激动剂（蝇蕈醇；80纳克）均未引起显著变化。这些结果表明，在上丘水平阻断GABA能传递会导致全身性非惊厥性癫痫发作受到抑制
