Cherqaoui Rabia, Husain Mehreen, Madduri Sujay, Okolie Pamela, Nunlee-Bland Gail, Williams James
Department of Internal Medicine, Howard University, Washington, DC 20060, USA.
Case Rep Hematol. 2013;2013:680459. doi: 10.1155/2013/680459. Epub 2013 Jun 11.
Vitamin B12 deficiency results in neuropsychiatric, hematologic, gynecologic, cardiovascular, and cutaneous manifestations. It is seen most commonly in the elderly, malabsorption diseases (>60% of all cases), vegans, and vegetarians. Manifestations of pernicious anemia may be similar to Addison disease and may lead to a misdiagnosis. Herein, we report two cases of vitamin B12 deficiency in which clinical features shared many similarities with Addison disease. Both patients presented with progressive darkening of hands and postural hypotension that reversed with replenishment of vitamin B12. Vitamin B12 deficiency should be considered in patients presenting with skin lesions especially with other coexisting autoimmune diseases.
维生素B12缺乏会导致神经精神、血液、妇科、心血管和皮肤方面的表现。它最常见于老年人、吸收不良疾病患者（占所有病例的60%以上）、纯素食者和素食者。恶性贫血的表现可能与艾迪生病相似，可能导致误诊。在此，我们报告两例维生素B12缺乏病例，其临床特征与艾迪生病有许多相似之处。两名患者均出现手部逐渐变黑和体位性低血压，补充维生素B12后症状逆转。对于出现皮肤病变尤其是伴有其他自身免疫性疾病的患者，应考虑维生素B12缺乏。
