Laux U, Roth H W, Krey H, Steinhardt B
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1975;195(1):33-40. doi: 10.1007/BF02390028.
300 rabbit corneas were burned for 1 minute by applying a filter paper of 10 mm diameter soaked in different concentrations of NaOH. The aqueous humor pH was then measured at certain time intervals and after different treatment methods until the physiologic pH of 7.6 was reached. The results were statistically analysed. Group 1, 2 and 3 were burned in 1n NaOH, 3n NaOH, and 6n NaOH respectively without any treatment. In these groups a "therapeutic" pH-level of 8.5 was measured on an average 0.5, 2.5 and 5 hours after the burn (Table 1 and Fig. 2). Group 4 and 5 again were burned with 6n NaOH. In group 4 the burn was followed by constant irrigation with physiologic saline solution by means of the Morgan Therapeutic Lens (Fig. 1a and b). With this regimen a pH of 8.5 was reached after 2.5 hours (Table 1 and Fig. 3). In group 5 the physiologic saline solutions was replaced by a buffer solution (Isogutt) and a pH of 8.5 was measured after only one hour (Table 1 and Fig. 3). Based upon these results it is felt that severe lye burns should be treated by constant irrigation with a buffer solution for several hours. A treatment that can easily be performed by use of the Morgan Therapeutic Lens.
将直径10毫米的滤纸浸泡在不同浓度的氢氧化钠中，然后用其烧灼300只兔角膜1分钟。随后在特定时间间隔以及采用不同治疗方法后测量房水pH值，直至达到7.6的生理pH值。对结果进行统计学分析。第1、2和3组分别在1N氢氧化钠、3N氢氧化钠和6N氢氧化钠中烧灼，未进行任何治疗。在这些组中，烧灼后平均分别在0.5小时、2.5小时和5小时测得“治疗性”pH值为8.5（表1和图2）。第4和5组再次用6N氢氧化钠烧灼。在第4组中，烧灼后通过摩根治疗镜片用生理盐水持续冲洗（图1a和b）。采用这种方案，2.5小时后达到pH值8.5（表1和图3）。在第5组中，生理盐水被缓冲溶液（Isogutt）替代，仅1小时后就测得pH值8.5（表1和图3）。基于这些结果，认为严重的碱烧伤应该用缓冲溶液持续冲洗数小时进行治疗。这种治疗可以通过使用摩根治疗镜片轻松进行。
