Liu Xin-hui, Yang Xiao
Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Lab of Chinical Research on Nepropathy, Ministry of Health, Guangzhou 510080, China.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Apr;33(4):554-8.
Aristolochic acid nephropathy (AAN), a progressive renal interstitial fibrosis frequently resulting in end stage renal disease, still remains a common chronic interstitial nephropathy in China. Therefore, great attention should be paid to AAN. This review summarized recent research progress of AAN in terms of in vivo aristolochic acid metabolism, epithelial mesenchymal transition, proteomics, immunity-inflammation, and autophagy, which will help to further understand the pathogenesis of AAN, and to search effective intervention targets.
马兜铃酸肾病(AAN)是一种常导致终末期肾病的进行性肾间质纤维化疾病,在中国仍是常见的慢性间质性肾病。因此,应高度重视AAN。本文综述了近年来AAN在体内马兜铃酸代谢、上皮-间质转化、蛋白质组学、免疫炎症和自噬方面的研究进展,这将有助于进一步了解AAN的发病机制,并寻找有效的干预靶点。