Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations Principles, Methods, and Applications in the Pharmaceutical Industry.
作者信息
Rowland M
机构信息
1] Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK [2] Department of Bioengineering and Therapeutic Sciences, School of Pharmacy and Medicine, University of California, San Francisco, California, USA.
出版信息
CPT Pharmacometrics Syst Pharmacol. 2013 Jul 10;2(7):e55. doi: 10.1038/psp.2013.29.
Abstract
摘要
相似文献
1
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations Principles, Methods, and Applications in the Pharmaceutical Industry.
CPT Pharmacometrics Syst Pharmacol. 2013 Jul 10;2(7):e55. doi: 10.1038/psp.2013.29.
2
Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification.
Drug Metab Dispos. 2015 Nov;43(11):1823-37. doi: 10.1124/dmd.115.065920. Epub 2015 Aug 21.
3
Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective.
Clin Pharmacol Ther. 2015 Mar;97(3):247-62. doi: 10.1002/cpt.37. Epub 2015 Jan 9.
4
Physiologically Based Pharmacokinetic Modeling of Therapeutic Proteins.
J Pharm Sci. 2017 Sep;106(9):2270-2275. doi: 10.1016/j.xphs.2017.03.038. Epub 2017 Apr 7.
5
PBPK modeling and simulation in drug research and development.
Acta Pharm Sin B. 2016 Sep;6(5):430-440. doi: 10.1016/j.apsb.2016.04.004. Epub 2016 Jun 23.
6
Physiologically Based Pharmacokinetic (PBPK) Modeling of Pharmaceutical Nanoparticles.
AAPS J. 2017 Jan;19(1):26-42. doi: 10.1208/s12248-016-0010-3. Epub 2016 Nov 10.
7
Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.
Paediatr Anaesth. 2011 Mar;21(3):291-301. doi: 10.1111/j.1460-9592.2010.03323.x.
8
Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs.
J Theor Biol. 2018 Aug 14;451:1-9. doi: 10.1016/j.jtbi.2018.04.032. Epub 2018 Apr 26.
9
Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
Pharmacol Ther. 2020 Jul;211:107541. doi: 10.1016/j.pharmthera.2020.107541. Epub 2020 Apr 1.
10
Predicting Oral Drug Absorption: Mini Review on Physiologically-Based Pharmacokinetic Models.
Pharmaceutics. 2017 Sep 26;9(4):41. doi: 10.3390/pharmaceutics9040041.
引用本文的文献
1
Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics.
J Pharmacokinet Pharmacodyn. 2025 Jun 12;52(4):35. doi: 10.1007/s10928-025-09980-9.
2
NNKcat: deep neural network to predict catalytic constants (Kcat) by integrating protein sequence and substrate structure with enhanced data imbalance handling.
Brief Bioinform. 2025 May 1;26(3). doi: 10.1093/bib/bbaf212.
3
DR5 disulfide bonding functions as a sensor and effector of protein folding stress.
Mol Cancer Res. 2024 Mar 19. doi: 10.1158/1541-7786.MCR-24-0756.
4
Evaluation of BCRP-Related DDIs Between Methotrexate and Cyclosporin A Using Physiologically Based Pharmacokinetic Modelling.
Drugs R D. 2025 Mar;25(1):1-17. doi: 10.1007/s40268-024-00495-1. Epub 2024 Dec 24.
5
Physiologically based pharmacokinetic modeling of drug-drug interactions between ritonavir-boosted atazanavir and rifampicin in pregnancy.
CPT Pharmacometrics Syst Pharmacol. 2024 Nov;13(11):1967-1977. doi: 10.1002/psp4.13268. Epub 2024 Nov 8.
6
Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats.
Front Vet Sci. 2024 Oct 2;11:1399043. doi: 10.3389/fvets.2024.1399043. eCollection 2024.
7
Infliximab in Inflammatory Bowel Disease: Leveraging Physiologically Based Pharmacokinetic Modeling in the Clinical Context.
Biomedicines. 2024 Sep 1;12(9):1974. doi: 10.3390/biomedicines12091974.
8
Modeling and comparison of dissolution profiles for different brands of albendazole boluses.
BMC Pharmacol Toxicol. 2024 Aug 9;25(1):48. doi: 10.1186/s40360-024-00774-2.
9
Extrapolation of lung pharmacokinetics of antitubercular drugs from preclinical species to humans using PBPK modelling.
J Antimicrob Chemother. 2024 Jun 3;79(6):1362-1371. doi: 10.1093/jac/dkae109.
10
Pharmacokinetic Modeling of Bepotastine for Determination of Optimal Dosage Regimen in Pediatric Patients with Allergic Rhinitis or Urticaria.
Pharmaceutics. 2024 Feb 27;16(3):334. doi: 10.3390/pharmaceutics16030334.
Zotero 插件