人参、白花蛇舌草和绒毛异翅藤提取物对老年大鼠海马细胞凋亡的影响。
Effects of Panax ginseng, Turnera diffusa and Heteropterys tomentosa extracts on hippocampal apoptosis of aged rats.
作者信息
Bezerra Andréia Gomes, Smaili Soraya Soubhi, Lopes Guiomar Silva, Carlini Elisaldo Araújo
出版信息
Einstein (Sao Paulo). 2013 Apr-Jun;11(2):163-7. doi: 10.1590/s1679-45082013000200005.
OBJECTIVE
To verify if the medicinal plants Panax ginseng C.A. Mey, Turnera diffusa Willd. ex Schult., and Heteropterys tomentosa O. Mach., which are amply used by the population as tonics and cognition enhancers, could have a protective effect on cell death by apoptosis, since this could be one of the mechanisms of action of these substances.
METHODS
Aged male Wistar rats (n = 24) were divided into four groups. Over 30 days, three groups received treatments with hydroalcoholic extracts of the plants, and one group received saline solution. A fifth group with young adult male Wistar rats (n = 4) received saline solution during the same period. Using the TUNEL technique, the percentage of apoptosis in the hippocampus of these animals was evaluated.
RESULTS
No differences were observed between the percentage of apoptotic cells in the hippocampus of aged animals and of young control animals. The percentage of apoptosis in the hippocampus of aged animals treated chronically with the extracts from the three plants also did not differ from the percentage of apoptosis in the hippocampus of the control group of aged animals.
CONCLUSION
Treatment with the hydroalcoholic extracts of Panax ginseng, Turnera diffusa, and Heteropterys tomentosa did not influence the apoptosis of the hippocampal cells of aged rats.
目的
验证人参（Panax ginseng C.A. Mey）、白花蛇舌草（Turnera diffusa Willd. ex Schult.）和绒毛异翅藤（Heteropterys tomentosa O. Mach.）这几种药用植物，因其被人们广泛用作滋补品和认知增强剂，是否可能通过凋亡对细胞死亡产生保护作用，因为这可能是这些物质的作用机制之一。
方法
将老年雄性Wistar大鼠（n = 24）分为四组。在30天内，三组接受植物水醇提取物治疗，一组接受生理盐水溶液。第五组年轻成年雄性Wistar大鼠（n = 4）在同一时期接受生理盐水溶液。使用TUNEL技术评估这些动物海马体中的凋亡百分比。
结果
老年动物和年轻对照动物海马体中凋亡细胞的百分比之间未观察到差异。用三种植物提取物长期处理的老年动物海马体中的凋亡百分比与老年动物对照组海马体中的凋亡百分比也没有差异。
结论
人参、白花蛇舌草和绒毛异翅藤的水醇提取物处理对老年大鼠海马体细胞的凋亡没有影响。
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