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蝎肽：新药开发的潜在用途。

Scorpion peptides: potential use for new drug development.

作者信息

Hmed Bennasr, Serria Hammami Turky, Mounir Zeghal Khaled

机构信息

Laboratory of Pharmacology, Medicine Faculty of Sfax, Street of Majida Boulila, 3029 Sfax, Tunisia.

出版信息

J Toxicol. 2013;2013:958797. doi: 10.1155/2013/958797. Epub 2013 Jun 15.

DOI:10.1155/2013/958797
PMID:23843786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3697785/
Abstract

Several peptides contained in scorpion fluids showed diverse array of biological activities with high specificities to their targeted sites. Many investigations outlined their potent effects against microbes and showed their potential to modulate various biological mechanisms that are involved in immune, nervous, cardiovascular, and neoplastic diseases. Because of their important structural and functional diversity, it is projected that scorpion-derived peptides could be used to develop new specific drugs. This review summarizes relevant findings improving their use as valuable tools for new drugs development.

摘要

蝎液中含有的几种肽表现出多样的生物活性，对其靶位点具有高度特异性。许多研究概述了它们对微生物的强效作用，并显示出它们调节参与免疫、神经、心血管和肿瘤疾病的各种生物机制的潜力。由于其重要的结构和功能多样性，预计蝎源肽可用于开发新的特效药物。本综述总结了相关研究结果，以促进其作为新药开发的宝贵工具的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ed/3697785/853dde99e2dd/JT2013-958797.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ed/3697785/ecfe83fc2e13/JT2013-958797.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ed/3697785/853dde99e2dd/JT2013-958797.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ed/3697785/ecfe83fc2e13/JT2013-958797.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07ed/3697785/853dde99e2dd/JT2013-958797.002.jpg

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Iran J Pharm Res. 2012 Winter;11(1):357-67.
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Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity.澳大利亚蝎子 Urodacus yaschenkoi 毒液的特性：成分的分子量分析、cDNA 序列和具有抗菌活性的肽。
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