Hmed Bennasr, Serria Hammami Turky, Mounir Zeghal Khaled
Laboratory of Pharmacology, Medicine Faculty of Sfax, Street of Majida Boulila, 3029 Sfax, Tunisia.
J Toxicol. 2013;2013:958797. doi: 10.1155/2013/958797. Epub 2013 Jun 15.
Several peptides contained in scorpion fluids showed diverse array of biological activities with high specificities to their targeted sites. Many investigations outlined their potent effects against microbes and showed their potential to modulate various biological mechanisms that are involved in immune, nervous, cardiovascular, and neoplastic diseases. Because of their important structural and functional diversity, it is projected that scorpion-derived peptides could be used to develop new specific drugs. This review summarizes relevant findings improving their use as valuable tools for new drugs development.
蝎液中含有的几种肽表现出多样的生物活性,对其靶位点具有高度特异性。许多研究概述了它们对微生物的强效作用,并显示出它们调节参与免疫、神经、心血管和肿瘤疾病的各种生物机制的潜力。由于其重要的结构和功能多样性,预计蝎源肽可用于开发新的特效药物。本综述总结了相关研究结果,以促进其作为新药开发的宝贵工具的应用。