Faculty of Health Sciences, Department of Microbiology, Hazara University, Mansehra, Pakistan.
Indian J Pharmacol. 2012 Jul-Aug;44(4):509-11. doi: 10.4103/0253-7613.99332.
Heterometrus xanthopus (Scorpion) is one of the most venomous and ancient arthropods. Its venom contains anti-microbial peptides like hadrurin, scorpine, Pandinin 1, and Pandinin 2 that are able to effectively kill multidrug-resistant pathogens. The present study was conducted to evaluate the anti-bacterial activity of H. xanthopus venom. Six Gram-positive and Gram-negative bacterial strains were tested against 1/100, 1/10, and 1/1 fractions of distilled water diluted and crude venom. 1/100 and 1/10 dilutions were not successful in any of the six bacterial strains studied while the 1/1 dilution was effective on Bacillus subtilis ATCC 6633, Salmonella typhimurium ATCC 14028, and Pseudomonas aeruginosa ATCC 27853 with highest zone of inhibition were obtained on B. subtilis. Crude venom was effective against Enterococcus faecalis ATCC 14506, B. subtilis, S. typhimurium, and P. aeruginosa. The most effective results were observed on B. subtilis.
中华婪步甲（Scorpion）是最具毒性和最古老的节肢动物之一。它的毒液含有抗菌肽，如 hadrurin、scorpine、Pandinin 1 和 Pandinin 2，能够有效杀死多种耐药病原体。本研究旨在评估中华婪步甲毒液的抗菌活性。六种革兰氏阳性和革兰氏阴性细菌菌株分别用 1/100、1/10 和 1/1 稀释的蒸馏水和粗毒液进行测试。在研究的六种细菌菌株中，1/100 和 1/10 稀释液均未成功，而 1/1 稀释液对枯草芽孢杆菌 ATCC 6633、鼠伤寒沙门氏菌 ATCC 14028 和铜绿假单胞菌 ATCC 27853 有效，其中对枯草芽孢杆菌的抑制作用最强。粗毒液对粪肠球菌 ATCC 14506、枯草芽孢杆菌、鼠伤寒沙门氏菌和铜绿假单胞菌有效。在枯草芽孢杆菌上观察到最有效的结果。
