Department of Dermatology, University Hospital Jena, 07743, Jena, Germany.
Contact Dermatitis. 2013 Dec;69(6):363-71. doi: 10.1111/cod.12103. Epub 2013 Jul 11.
Occupational skin contact with lipophilic substances is a risk factor for the development of irritant hand dermatitis. Skin protection creams form part of the personal protective equipment, and some are claimed to protect against lipophilic irritants. However, their benefit against solvents is under debate.
To evaluate the efficacy of barrier creams claimed to protect against lipophilic irritants in a newly developed repetitive irritation model.
Thirty-five healthy volunteers were enrolled in a double-blind, randomized study, and six barrier creams were evaluated against irritation induced by two occupationally relevant model solvents, n-octane and cumene. Clinical scoring and bioengineering methods (capacitance and transepidermal water loss measurements) were used to quantify the irritant reactions.
None of the test products offered protection against n-octane-induced clinical irritation or stratum corneum dehydration. One test product significantly aggravated the skin irritation induced by both irritants, and a second one enhanced dehydration induced by n-octane only.
The lack of efficacy and the aggravation of skin irritation induced by two of six test products stress the need for standardized efficacy testing of occupational skin protection products.
职业性皮肤接触脂溶性物质是刺激性接触性皮炎发展的一个危险因素。皮肤保护乳膏是个人防护设备的一部分，一些据称可预防脂溶性刺激物。然而，它们对溶剂的防护作用仍存在争议。
在新开发的重复性刺激模型中评估据称可预防脂溶性刺激物的屏障乳膏的功效。
35 名健康志愿者参加了一项双盲、随机研究，评估了 6 种屏障乳膏对两种职业相关模型溶剂（正辛烷和异丙苯）引起的刺激的效果。临床评分和生物工程方法（电容和经皮水分流失测量）用于量化刺激反应。
没有一种测试产品能预防正辛烷引起的临床刺激或角质层脱水。一种测试产品显著加重了两种刺激物引起的皮肤刺激，另一种产品仅加重了正辛烷引起的脱水。
六种测试产品中有两种缺乏功效并加重皮肤刺激，这突出表明需要对职业性皮肤保护产品进行标准化功效测试。
