Wigger-Alberti W, Rougier A, Richard A, Elsner P
Department of Dermatology, Friedrich-Schiller-University, Jena, Germany.
Acta Derm Venereol. 1998 Jul;78(4):270-3. doi: 10.1080/000155598441846.
The effect of 3 protective creams and petrolatum was tested in a repetitive irritation test. On 15 healthy volunteers, the irritants (sodium lauryl sulfate 10%, sodium hydroxide 0.5%, lactic acid 15%, and toluene undiluted) were applied on the paravertebral skin of the mid-back after 30 min pretreatment with the products tested. The volunteers were treated for 9 days. The irritant cutaneous reactions were quantified by erythema score, transepidermal water loss, and chromametry. The results showed a specific profile of efficacy against the 4 irritants used. For all creams a significant protective effect was obtained against irritation by sodium lauryl sulfate, sodium hydroxide and lactic acid in different degrees. Less efficacy was observed against toluene. Even an amplification of inflammation by pretreatment with 1 product could be demonstrated. The results indicate that a 1-week period of cumulative irritation might be enough to evaluate the efficacy of protective creams against most irritants.
在一项重复性刺激试验中测试了3种防护霜和凡士林的效果。对15名健康志愿者，在用受试产品预处理30分钟后，将刺激物（10%月桂醇硫酸酯钠、0.5%氢氧化钠、15%乳酸和未稀释的甲苯）涂抹于背部中线上的椎旁皮肤。志愿者接受治疗9天。通过红斑评分、经表皮水分流失和色度测定对刺激性皮肤反应进行量化。结果显示了针对所使用的4种刺激物的特定疗效特征。对于所有防护霜，均不同程度地获得了针对月桂醇硫酸酯钠、氢氧化钠和乳酸刺激的显著保护作用。观察到对甲苯的疗效较差。甚至可以证明用1种产品预处理会加剧炎症。结果表明，1周的累积刺激期可能足以评估防护霜对大多数刺激物的疗效。
