Institute of Cytology, Russian Academy of Sciences, St Petersburg, Russia.
Int J Hyperthermia. 2013 Aug;29(5):399-408. doi: 10.3109/02656736.2013.807439. Epub 2013 Jul 11.
Heat shock protein 70 (HSPA family) is a multi-functional protein which protects individual cells from proteotoxic shock and the whole organism from microbial, viral and oncogenic pathogens. These diverse functions may depend upon 'chaperone' activity that allows Hsp70 to regulate the mechanism of damaged protein recovery or utilisation inside a cell and to be a potent adjuvant, stimulating immune activity against a variety of viral or tumour antigens. The aim of this review is to present recent data on specific roles of intracellular and extracellular Hsp70 in cancerous tissue.
The data presented in this paper show that endogenous Hsp70 protects cancer cells of different origins from a variety of cytotoxic threats including cancer cell therapeutics. In contrast, however, Hsp70 released from stressed cancer cells can serve as a danger signal or may recruit cells responsible for the generation of innate and adaptive immune responses against tumour cells.
热休克蛋白 70（HSPA 家族）是一种多功能蛋白，可保护个体细胞免受蛋白毒性休克的影响，并保护整个机体免受微生物、病毒和致癌病原体的侵害。这些不同的功能可能取决于“伴侣”活性，该活性允许 Hsp70 调节细胞内受损蛋白恢复或利用的机制，并成为一种有效的佐剂，刺激针对多种病毒或肿瘤抗原的免疫活性。本文的目的是介绍细胞内和细胞外 Hsp70 在癌组织中的特定作用的最新数据。
本文介绍的数据表明，内源性 Hsp70 可保护不同来源的癌细胞免受多种细胞毒性威胁的影响，包括癌细胞治疗药物。然而，相反，从应激癌细胞中释放的 Hsp70 可以作为危险信号，或者可以招募负责产生针对肿瘤细胞的固有和适应性免疫反应的细胞。
