Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Nanoscale. 2013 Sep 7;5(17):7844-8. doi: 10.1039/c3nr02101g.
Graphene related materials have been widely employed as highly efficient transducers for biorecognition. Here we show a conceptually new approach of using graphene oxide nanoplatelets (50 × 50 nm) as voltammetric inherently active labels for specific protein-target molecule recognition. This proof-of-principle is demonstrated by biotin-avidin recognition, which displays that graphene oxide nanoplatelet labels show excellent selectivity. Therefore, it is expected that inherently electroactive graphene oxide nanoplatelet labels will play a similar role as electroactive gold nanoparticle labels which were developed more than a decade ago.
石墨烯相关材料已被广泛用作生物识别的高效换能器。在这里，我们展示了一种新概念，使用氧化石墨烯纳米片（50×50nm）作为伏安法固有的活性标签，用于特定蛋白质靶分子的识别。通过生物素-亲和素识别证明了这一原理，该识别显示氧化石墨烯纳米片标签具有优异的选择性。因此，可以预期固有的电活性氧化石墨烯纳米片标签将发挥与十多年前开发的电活性金纳米粒子标签类似的作用。
