Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Database (Oxford). 2013 Jul 11;2013:bat052. doi: 10.1093/database/bat052. Print 2013.
Type 2 diabetes mellitus (T2D), affecting >90% of the diabetic patients, is one of the major threats to human health. A comprehensive understanding of the mechanisms of T2D at molecular level is essential to facilitate the related translational research. Here, we introduce a comprehensive and up-to-date knowledgebase for T2D, i.e. T2D@ZJU. T2D@ZJU contains three levels of heterogeneous connections associated with T2D, which is retrieved from pathway databases, protein-protein interaction databases and literature, respectively. In current release, T2D@ZJU contains 1078 T2D related entities such as proteins, protein complexes, drugs and others together with their corresponding relationships, which include 3069 manually curated connections, 14,893 protein-protein interactions and 26,716 relationships identified by text-mining technology. Moreover, T2D@ZJU provides a user-friendly web interface for users to browse and search data. A Cytoscape Web-based interactive network browser is available to visualize the corresponding network relationships between T2D-related entities. The functionality of T2D@ZJU is shown by means of several case studies. Database URL: http://tcm.zju.edu.cn/t2d.
2 型糖尿病（T2D）影响了超过 90%的糖尿病患者，是人类健康的主要威胁之一。全面了解 T2D 在分子水平上的机制对于促进相关的转化研究至关重要。在这里，我们介绍了一个全面且最新的 T2D 知识库，即 T2D@ZJU。T2D@ZJU 包含三个与 T2D 相关的异构连接层次，分别从途径数据库、蛋白质-蛋白质相互作用数据库和文献中检索得到。在当前版本中，T2D@ZJU 包含 1078 个与 T2D 相关的实体，如蛋白质、蛋白质复合物、药物等，以及它们对应的关系，包括 3069 条人工策管的连接、14893 条蛋白质-蛋白质相互作用和 26716 条通过文本挖掘技术识别的关系。此外，T2D@ZJU 为用户提供了一个用户友好的网络界面，用于浏览和搜索数据。还提供了一个基于 Cytoscape 的交互式网络浏览器，用于可视化 T2D 相关实体之间的对应网络关系。通过几个案例研究展示了 T2D@ZJU 的功能。数据库网址：http://tcm.zju.edu.cn/t2d。
