Department of Ophthalmology, Lund University, and Skåne University Hospital, Lund, Sweden.
Invest Ophthalmol Vis Sci. 2013 Sep 9;54(9):6112-7. doi: 10.1167/iovs.13-12376.
We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsilateral and contralateral ophthalmic arteries and that there may be an interconnecting artery between the eyes.
The external carotid system of 6 pigs was catheterized using a fluoroscopy-monitored, transfemoral, endovascular approach. Vascular occlusion was achieved in the ophthalmic artery using coils. The effect of occlusion was examined using angiography and multifocal electroretinography (mfERG).
During angiography of the ophthalmic artery on one side, contrast filling was seen in the retinas on both sides, suggesting that the ophthalmic artery on one side may supply both retinas. A blood vessel connecting the eyes was visualized. The mfERG recordings indicated that the use of coiling to occlude the ophthalmic artery had greater ischemic effects in eyes that may depend mainly on the ipsilateral ophthalmic artery for blood supply and had smaller ischemic effects in retinas that received blood from both the ipsilateral and contralateral ophthalmic arteries via the interconnecting vessel.
The blood supply to the retina may originate from both the ipsilateral and contralateral ophthalmic arteries in the pig. There is an interindividual variability in the ischemic effect of occlusion depending on the architecture of the vasculature. These findings may be important in the development of new animal models of experimental retinal ischemia because arterial occlusion in one eye may affect the blood supply to the contralateral eye.
我们最近提出了一种经股动脉腔内栓塞技术，用于诱导猪实验性视网膜缺血。在缺血程度上存在很大差异。据推测，视网膜的血液供应可能来自同侧和对侧眼动脉，并且眼睛之间可能存在一条连接动脉。
使用透视监测的经股动脉腔内入路对 6 头猪的颈外系统进行了导管插入。使用线圈闭塞眼动脉以实现闭塞。使用血管造影和多焦视网膜电图（mfERG）检查闭塞的效果。
在一侧眼动脉的血管造影期间，在两侧视网膜中均可见造影剂充盈，表明一侧眼动脉可能为两侧视网膜供血。可视化了连接眼睛的血管。mfERG 记录表明，使用线圈闭塞眼动脉对主要依赖同侧眼动脉供血的眼睛具有更大的缺血作用，而对通过连接血管从同侧和对侧眼动脉获得血液的视网膜的缺血作用较小。
猪的视网膜血液供应可能来自同侧和对侧眼动脉。闭塞的缺血效应存在个体间差异，这取决于血管结构。这些发现对于实验性视网膜缺血的新动物模型的发展可能很重要，因为一只眼的动脉闭塞可能会影响对侧眼的血液供应。
