Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, DenmarkDepartment of Vascular Surgery, Rigshospitalet, University of Copenhagen, DenmarkGlostrup Stroke Unit, Department of Neurology, Glostrup Hospital, University of Copenhagen, DenmarkNational Eye Clinic, Kennedy Center, Glostrup, Denmark.
Acta Ophthalmol. 2013 Dec;91(8):728-32. doi: 10.1111/j.1755-3768.2012.02438.x. Epub 2012 Jun 8.
To examine retinal function in relation to retinal perfusion pressure in patients with carotid artery stenosis.
Thirteen patients with carotid artery stenosis without clinical eye disease underwent assessment of ophthalmic artery systolic blood pressure (OSP) by ocular pneumoplethysmography, carotid artery obstructive disease by ultrasonography, intraocular pressure by applanation tonometry, retinal perfusion by fluorescein angiography and retinal function by multifocal electroretinography (mfERG). Data analysis compared the eye on the most stenotic side with the fellow eye in the same patient.
Ophthalmic systolic pressure was 95.8 ± 13.1 mmHg on the side with the highest degree of carotid artery stenosis (mean 94.0%) and 111.7 ± 10.3 mmHg in the fellow eyes on the side with the lesser degree of stenosis (mean 33.9%). Summed mfERG implicit times (N1 and P1) were 3.4% and 2.0% longer (p = 0.013 and 0.021), and N1 and P1 amplitudes were 18.0% and 16.0% (p = 0.0041 and 0.020) lower in eyes on the side with the higher stenosis compared with the contralateral eyes. Shorter implicit times and higher amplitudes were correlated with higher brachial systolic arterial blood pressure (p = 0.0028, 0.011, 0.041 for N1, P1, N2 implicit times, respectively, and p = 0.0086, 0.016, 0.040 for N1, P1, N2 for amplitudes, respectively, corrected for OSP).
Cone function deviation was observed in clinically healthy eyes on the side with highest degree of carotid artery stenosis and was found correlated to arterial blood pressure.
研究颈动脉狭窄患者视网膜功能与视网膜灌注压的关系。
对 13 例无临床眼部疾病的颈动脉狭窄患者，采用眼动脉血压描记法（ocular pneumoplethysmography）测量眼动脉收缩压（OSP），超声检查颈动脉阻塞性疾病，眼压计测量眼压，荧光素血管造影测量视网膜灌注，多焦视网膜电图（mfERG）测量视网膜功能。数据分析将患者患侧最狭窄眼与对侧眼进行比较。
患侧颈动脉狭窄程度最高（平均 94.0%）的眼的眼动脉收缩压为 95.8 ± 13.1mmHg，狭窄程度较低（平均 33.9%）的对侧眼的眼动脉收缩压为 111.7 ± 10.3mmHg。双侧眼的 mfERG 总和隐时（N1 和 P1）分别长 3.4%和 2.0%（p=0.013 和 0.021），双侧眼的 N1 和 P1 振幅分别低 18.0%和 16.0%（p=0.0041 和 0.020）。较高的狭窄侧眼的隐时较短，振幅较高，与较高的肱动脉收缩压相关（p=0.0028、0.011、0.041 分别为 N1、P1、N2 隐时，p=0.0086、0.016、0.040 分别为 N1、P1、N2 振幅，校正 OSP）。
在颈动脉狭窄程度最高的患侧临床健康眼中观察到了视锥细胞功能偏差，并且发现与动脉血压相关。
