硫唑嘌呤与别嘌醇：一种潜在的危险组合。
Azathioprine and allopurinol: a potentially dangerous combination.
作者信息
Venkat Raman G, Sharman V L, Lee H A
机构信息
Department of Renal Medicine, University of Southampton, St Mary's Hospital, Portsmouth, UK.
出版信息
J Intern Med. 1990 Jul;228(1):69-71. doi: 10.1111/j.1365-2796.1990.tb00195.x.
Abstract
We report the association of leucopenia and anaemia in five patients given a combination of azathioprine and allopurinol. Three subjects were renal transplant recipients with mild to moderate impairment of graft function. The complication appeared between 4 and 6 weeks following initiation of the combination therapy. Discontinuation of one of the two drugs resulted in full recovery within 4-8 weeks.
摘要
我们报告了5例接受硫唑嘌呤和别嘌醇联合治疗的患者出现白细胞减少和贫血的情况。其中3例为肾移植受者，移植肾功能有轻度至中度损害。并发症出现在联合治疗开始后的4至6周。停用两种药物中的一种后，患者在4至8周内完全康复。
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