慢性低压缺氧大鼠的心室功能与葡萄糖摄取
Ventricular performance and glucose uptake in rats during chronic hypobaric hypoxia.
作者信息
Hurford W E, Crosby G, Strauss H W, Jones R, Lowenstein E
机构信息
Anesthesia Service, Massachusetts General Hospital, Boston 02114.
出版信息
J Nucl Med. 1990 Aug;31(8):1344-51.
To identify changes of ventricular performance and their relationship to myocardial glucose uptake in Sprague-Dawley rats exposed to hypobaric hypoxia, radionuclide angiocardiograms (n = 34) and 2-[14C]deoxyglucose (2-[14C]DG) autoradiography (n = 14) were performed on rats maintained either for two weeks in air at 380 mmHg (hypoxic group), two weeks in hypobaric hypoxia followed by two weeks of air (recovered group), or in air (control group). Right ventricular ejection fraction (RVEF) was 66% +/- 2% (mean +/- s.e.m.) in controls, 40% +/- 3% during hypoxia, and 60% +/- 2% in recovered rats. LVEF remained unchanged. In controls, RV 2-[14C]DG uptake was 77% +/- 3% of LV uptake. During hypoxia, 2-[14C]DG uptake increased. This increase was greater within the RV than the LV and septum (85 +/- 16% versus 51 +/- 10%, p less than 0.005). The alterations of RV 2-[14C]DG uptake correlated with systolic pulmonary artery pressure (r = 0.77, p = 0.002).
为了确定低压缺氧环境下Sprague-Dawley大鼠心室功能的变化及其与心肌葡萄糖摄取的关系，对三组大鼠进行了放射性核素心血管造影（n = 34）和2-[¹⁴C]脱氧葡萄糖（2-[¹⁴C]DG）放射自显影（n = 14）实验。三组大鼠分别为：在380 mmHg的常压空气中饲养两周的大鼠（对照组）；在低压缺氧环境下饲养两周，然后在常压空气中饲养两周的大鼠（恢复组）；在低压缺氧环境下饲养两周的大鼠（缺氧组）。对照组的右心室射血分数（RVEF）为66%±2%（平均值±标准误），缺氧期间为40%±3%，恢复组大鼠为60%±2%。左心室射血分数（LVEF）保持不变。在对照组中，右心室2-[¹⁴C]DG摄取量为左心室摄取量的77%±3%。缺氧期间，2-[¹⁴C]DG摄取量增加。右心室内的增加幅度大于左心室和室间隔（分别为85±16%和51±10%，p<0.005）。右心室2-[¹⁴C]DG摄取量的变化与收缩期肺动脉压相关（r = 0.77，p = 0.002）。
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