意大利拉齐奥地区 2008 年外科抗菌预防用药适宜性：一项多中心研究。
Appropriateness of surgical antimicrobial prophylaxis in the Latium region of Italy, 2008: a multicenter study.
机构信息
Epidemiology Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy.
出版信息
Surg Infect (Larchmt). 2013 Aug;14(4):381-4. doi: 10.1089/sur.2012.189. Epub 2013 Jul 12.
BACKGROUND
There is still wide variability in surgical antimicrobial prophylaxis (SAP) practice by different surgical teams and specialties, with potential impact on adverse events and the emergence of antibiotic resistance.
METHODS
We assessed SAP appropriateness in a regional prospective multicenter study on the basis of the agreement of the Surgical Care Improvement Project indicators (SCIP-Inf) with Italian guidelines (GL).
RESULTS
Prophylaxis was administered in 2,664 of 2,835 procedures (94%): In 2,346 of 2,468 (95%) as indicated and in 318 of 367 (86.6%) in which they were not indicated. The SCIP-Inf1 (timing), SCIP-Inf2 (antibiotic choice), and SCIP-Inf3 (duration) were in agreement with GL in 1,172 (50%), 1,983 (84.5%), and 1,121 (48%) of 2,346 procedures, respectively.
CONCLUSIONS
These results suggest the need for implementation of an antimicrobial stewardship program in this surgical setting.
背景
不同外科团队和专业的手术抗菌预防（SAP）实践仍存在广泛差异，这可能对不良事件和抗生素耐药性的出现产生影响。
方法
我们根据外科护理改进项目指标（SCIP-Inf）与意大利指南（GL）的一致性，在一项区域性前瞻性多中心研究中评估 SAP 的适当性。
结果
在 2,835 例手术中的 2,664 例（94%）中给予了预防措施：在 2,468 例中的 2,346 例（95%）中为指征性，在 367 例中的 318 例（86.6%）中为非指征性。SCIP-Inf1（时机）、SCIP-Inf2（抗生素选择）和 SCIP-Inf3（持续时间）与 GL 一致的分别为 1,172 例（50%）、1,983 例（84.5%）和 1,121 例（48%）。
结论
这些结果表明，在这种外科环境中需要实施抗菌药物管理计划。
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