Lobodzińska M, Biernacka I, Skurska Z
Arch Immunol Ther Exp (Warsz). 1975;23(2):225-31.
Studies on interferon from rat serum sensitive to pH 2-0 showed the following: 1) Its action is stronger in cultures of heterologous L cells than in rat fibroblast cultures. 2) Resistance acquired under the influence of interferon lasts longer in a heterologous than in a homologous system. 3) Actinomycin D added to cultures after 4 hours of contact with interferon inhibits its activity in L cells, and potentiates its activity in RE cells. 4) In rat embryonic cells treated with interferon, interferon production following induction with ND virus is blocked. Similar blocking was observed in cultures of L cells after 24-hour priming; after 6 hours of exposure of L cells to rat interferon, on the other hand, production of interferon was enhanced.
对大鼠血清中对pH 2.0敏感的干扰素的研究结果如下：1）其在异源L细胞培养物中的作用比在大鼠成纤维细胞培养物中更强。2）在干扰素影响下获得的抗性在异源系统中持续的时间比在同源系统中更长。3）在与干扰素接触4小时后添加到培养物中的放线菌素D会抑制其在L细胞中的活性，并增强其在RE细胞中的活性。4）在用干扰素处理的大鼠胚胎细胞中，新城疫病毒诱导后的干扰素产生被阻断。在L细胞培养物经24小时预处理后也观察到类似的阻断现象；另一方面，L细胞在暴露于大鼠干扰素6小时后，干扰素的产生增强。
