用于估算高原通气补偿点的分钟通气量与心率关系：一项初步研究。

Minute ventilation and heart rate relationship for estimation of the ventilatory compensation point at high altitude: a pilot study.

作者信息

Valli Gabriele, Internullo Mattia, Ferrazza Alessandro M, Onorati Paolo, Cogo Annalisa, Palange Paolo

机构信息

Lung Function Unit, Department of Public Health and Infectious Diseases, University of Rome "La Sapienza", viale Università 37, Rome, 00185, Italy.

出版信息

Extrem Physiol Med. 2013 Mar 1;2(1):7. doi: 10.1186/2046-7648-2-7.

DOI:10.1186/2046-7648-2-7

PMID:23849656

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3710187/

Abstract

BACKGROUND

The ventilatory compensation point (VCP) is an exercise threshold which has been used in the design of training programs in sports medicine and rehabilitation. We recently demonstrated that changes in the slope of the minute ventilation to heart rate relationship (ΔV˙E/ΔHR) can be utilized for estimation of the VCP during incremental exercise at sea level (SL). We hypothesized that in hypoxic conditions, such as high altitude (HA), VCP can be also reliably estimated by ΔV˙E/ΔHR.

METHODS

At SL and on immediate ascent to HA (5,050 m), six healthy subjects (42 ± 14 SD years) performed a maximal incremental exercise test on a cycle ergometer; O2 uptake (V˙O2), CO2 output (V˙CO2), V˙E, and HR were measured breath-by-breath. The ΔV˙E/ΔHR method for VCP estimation was compared to the standard method using the ventilatory equivalent for CO2 (V˙E/V˙CO2) and end-tidal PCO2 (PETCO2). The ΔV˙E/ΔHR slope values below (S1) and above (S2) VCP were computed by linear regression analysis.

RESULTS

A significant difference between S1 and S2 was observed, at SL and HA, for both the ΔV˙E/ΔHR and V˙E/V˙CO2 methods for VCP estimation. A good agreement between the two methods (ΔV˙E/ΔHR vs. V˙E/V˙CO2) was found for both environmental conditions; the mean difference ± 2 SD of V˙O2 at VCP (VCP-V˙O2) was -22 ± 112 ml/min at SL and 39 ± 81 ml/min at HA. The VCP-V˙O2 was significantly lower at HA compared to SL; in addition, S1 and S2 mean values were significantly higher at HA compared to SL.

CONCLUSION

At HA, VCP may be reliably estimated by the ΔV˙E/ΔHR method.

摘要

背景

通气补偿点（VCP）是一个运动阈值，已用于运动医学和康复训练计划的设计中。我们最近证明，在海平面（SL）进行递增运动时，分钟通气量与心率关系的斜率变化（ΔV˙E/ΔHR）可用于估算VCP。我们假设，在低氧条件下，如高海拔（HA），VCP也可通过ΔV˙E/ΔHR可靠地估算。

方法

在海平面和立即上升到高海拔（5050米）时，六名健康受试者（42±14标准差岁）在自行车测力计上进行了最大递增运动测试；逐次呼吸测量摄氧量（V˙O2）、二氧化碳排出量（V˙CO2）、V˙E和心率。将用于估算VCP的ΔV˙E/ΔHR方法与使用二氧化碳通气当量（V˙E/V˙CO2）和呼气末PCO2（PETCO2）的标准方法进行比较。通过线性回归分析计算VCP以下（S1）和以上（S2）的ΔV˙E/ΔHR斜率值。

结果

在海平面和高海拔时，对于估算VCP的ΔV˙E/ΔHR和V˙E/V˙CO2方法，均观察到S1和S2之间存在显著差异。在两种环境条件下，两种方法（ΔV˙E/ΔHR与V˙E/V˙CO2）之间均发现良好的一致性；VCP时V˙O2的平均差异±2标准差（VCP-V˙O2）在海平面为-22±112毫升/分钟，在高海拔为39±81毫升/分钟。与海平面相比，高海拔时的VCP-V˙O2显著更低；此外，与海平面相比，高海拔时S1和S2的平均值显著更高。