Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China.
Psychiatry Res. 2013 Dec 15;210(2):590-3. doi: 10.1016/j.psychres.2013.06.027. Epub 2013 Jul 11.
This study was designed to explore the relationship between pituitary microadenoma and psychosis and to evaluate the role that prolactin plays in pituitary microadenoma and comorbid psychosis. In this study, the prolactin serum levels were compared between 74 first-episode drug-naive patients with a pituitary microadenoma with psychosis (PMP), and 58 patients with a pituitary microadenoma with no psychosis (PMNP). Patients with PMP had significantly higher prolactin serum levels; male patients with PMP had a mean [S.D.] prolactin level of 705.4 uIU/ml [226.1] vs. 433.1 uIU/ml [58.4] for male patients with PMNP, while female patients with PMP had a mean prolactin level of 1890.1 uIU/ml [1138.7] vs. 978.6 uIU/ml [657.9] for female patients with PMNP. The size of microadenoma in the patients with PMP was larger than those in the patients with PMNP, regardless of sex. Our data suggested that a higher prolactin serum level is a characteristic of first-episode neuroleptic-naive patients with PMP.
本研究旨在探讨垂体微腺瘤与精神病的关系，并评估催乳素在垂体微腺瘤和伴发精神病中的作用。在这项研究中，我们比较了 74 例首次发病、未经抗精神病药物治疗的伴有垂体微腺瘤的精神病患者（PMP）和 58 例伴有垂体微腺瘤但无精神病的患者（PMNP）的催乳素血清水平。PMP 患者的催乳素血清水平显著升高；PMP 男性患者的平均（标准差）催乳素水平为 705.4 uIU/ml[226.1]，而 PMNP 男性患者的催乳素水平为 433.1 uIU/ml[58.4]；PMP 女性患者的平均催乳素水平为 1890.1 uIU/ml[1138.7]，而 PMNP 女性患者的催乳素水平为 978.6 uIU/ml[657.9]。无论性别如何，PMP 患者的微腺瘤大小均大于 PMNP 患者。我们的数据表明，催乳素血清水平升高是首发未经抗精神病药物治疗的伴有垂体微腺瘤的精神病患者的特征。
