University of Basel Psychiatric Clinics, Basel, Switzerland.
Psychol Med. 2013 Dec;43(12):2571-82. doi: 10.1017/S0033291713000226. Epub 2013 Apr 17.
Hyperprolactinemia is frequent in patients with schizophrenic psychoses. It is usually regarded as an adverse effect of antipsychotics but has recently also been shown in patients without antipsychotic medication. Our objective was to test whether hyperprolactinemia occurs in antipsychotic-naive first-episode patients (FEPs).
In the framework of the European First Episode Schizophrenia Trial (EUFEST), 249 out of 498 FEPs were eligible for this study, of whom 74 were antipsychotic naive. All patients were investigated regarding their serum prolactin levels with immunoassays standardized against the 3rd International Reference Standard 84/500.
Twenty-nine (39%) of the 74 antipsychotic-naive patients showed hyperprolactinemia not explained by any other reason, 11 (50%) of 22 women and 18 (35%) of 52 men.
Hyperprolactinemia may be present in patients with schizophrenic psychoses independent of antipsychotic medication. It might be stress induced. As enhanced prolactin can increase dopamine release through a feedback mechanism, this could contribute to explaining how stress can trigger the outbreak of psychosis.
高催乳素血症在精神分裂症患者中很常见。它通常被认为是抗精神病药物的不良反应，但最近也在没有抗精神病药物治疗的患者中出现。我们的目的是测试抗精神病药物初发患者（FEP）是否会出现高催乳素血症。
在欧洲首发精神分裂症试验（EUFEST）的框架内，498 名 FEP 中有 249 名符合本研究条件，其中 74 名患者为抗精神病药物初发。所有患者均通过免疫测定法检测血清催乳素水平，该测定法以第 3 届国际参考标准品 84/500 为标准进行标准化。
74 名抗精神病药物初发患者中，有 29 名（39%）出现不明原因的高催乳素血症，其中 22 名女性中有 11 名（50%），52 名男性中有 18 名（35%）。
高催乳素血症可能存在于抗精神病药物治疗的精神分裂症患者中。它可能是由压力引起的。由于增强的催乳素可以通过反馈机制增加多巴胺的释放，这可以帮助解释应激如何引发精神病的发作。
