IEEE Trans Biomed Circuits Syst. 2010 Dec;4(6):340-9. doi: 10.1109/TBCAS.2010.2081364.
Glaucoma is a detrimental disease that causes blindness in millions of people worldwide. There are numerous treatments to slow the condition but none are totally effective and all have significant side effects. Currently, a continuous monitoring device is not available, but its development may open up new avenues for treatment. This work focuses on the design and fabrication of an active glaucoma intraocular pressure (IOP) monitor that is fully wireless and implantable. Major benefits of an active IOP monitoring device include the potential to operate independently from an external device for extended periods of time and the possibility of developing a closed-loop monitoring and treatment system. The fully wireless operation is based off using gigahertz-frequency electromagnetic wave propagation, which allows for an orientation independent transfer of power and data over reasonable distances. Our system is comprised of a micro-electromechanical systems (MEMS) pressure sensor, a capacitive power storage array, an application-specific integrated circuit designed on the Texas Instruments (TI) 130 nm process, and a monopole antenna all assembled into a biocompatible liquid-crystal polymer-based tadpole-shaped package.
青光眼是一种有害的疾病，它导致全球数百万人失明。有许多治疗方法可以减缓病情，但没有一种方法是完全有效的，而且所有方法都有明显的副作用。目前，还没有可连续监测的设备，但它的开发可能为治疗开辟新途径。这项工作专注于设计和制造完全无线和可植入的主动青光眼眼内压（IOP）监测器。主动 IOP 监测器的主要优点包括有潜力在较长时间内独立于外部设备运行，以及开发闭环监测和治疗系统的可能性。完全无线操作基于千兆赫兹频率的电磁波传播，允许在合理距离内进行无方向的功率和数据传输。我们的系统由微机电系统（MEMS）压力传感器、电容式储能阵列、基于德州仪器（TI）130nm 工艺设计的专用集成电路以及单极天线组成，全部组装到基于液晶聚合物的蝌蚪形生物相容封装中。
