Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, PR China.
Nutr Clin Pract. 2013 Aug;28(4):499-505. doi: 10.1177/0884533613487218. Epub 2013 Jul 12.
Exclusive enteral nutrition (EEN) is an effective and safe remission induction treatment for Crohn's disease in adults. Its influence on adults' health-related quality of life remains unknown. The aim of this study was to determine the effect of EEN on health-related quality of life in adults with active Crohn's disease.
Patients recruited were treated with a polymeric enteral feed that was taken orally in the daytime and via a self-intubated nasogastric tube at night for 4 weeks. Prospective evaluation of disease activity (Crohn's Disease Activity Index, CDAI) and health-related quality of life (Inflammatory Bowel Disease Questionnaire, IBDQ) were performed at enrollment and after 4 weeks of treatment. Patients' feelings about EEN were also investigated through 2 questions.
Thirteen patients were treated with 4-week EEN. They had a significant improvement in total IBDQ score (P < .001) and all IBDQ dimensions: bowel symptoms (P < .001), systemic symptoms (P < .001), social function (P = .003), and emotional status (P < .001), with 11 patients (84.6%) achieving clinical remission after treatment. In addition, 8 patients (61.5%) expressed their willingness to receive this 4-week EEN treatment again to induce remission if the disease relapsed. The IBDQ correlated significantly with the CDAI at 4 weeks.
A 4-week treatment of EEN improves health-related quality of life significantly in adults with active Crohn's disease and was acceptable by most patients.
肠内营养专论（EEN）是一种有效的、安全的成人克罗恩病缓解诱导治疗方法。但其对成人健康相关生活质量的影响尚不清楚。本研究旨在确定 EEN 对活动期克罗恩病成人健康相关生活质量的影响。
招募的患者接受了 4 周的聚合物肠内喂养，白天口服，晚上通过自我插管鼻胃管进行。在入组时和治疗 4 周后进行疾病活动度（克罗恩病活动指数，CDAI）和健康相关生活质量（炎症性肠病问卷，IBDQ）的前瞻性评估。通过 2 个问题还调查了患者对 EEN 的感受。
13 例患者接受了 4 周的 EEN 治疗。他们的 IBDQ 总分（P<0.001）和所有 IBDQ 维度均显著改善：肠道症状（P<0.001）、全身症状（P<0.001）、社会功能（P=0.003）和情绪状态（P<0.001），治疗后 11 例（84.6%）患者达到临床缓解。此外，8 例（61.5%）患者表示如果疾病复发，愿意再次接受这种 4 周的 EEN 治疗以诱导缓解。IBDQ 与 4 周时的 CDAI 显著相关。
EEN 治疗 4 周可显著改善活动期克罗恩病成人的健康相关生活质量，大多数患者可接受。
