二烯丙基二硫通过上调 miR-200b 和 miR-22 抑制 Wnt-1 信号通路抑制人胃癌的增殖并诱导凋亡。
Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22.
机构信息
Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China; Cancer Research Institute, University of South China, Hengyang, Hunan, People's Republic of China.
出版信息
Cancer Lett. 2013 Oct 28;340(1):72-81. doi: 10.1016/j.canlet.2013.06.027. Epub 2013 Jul 9.
The purpose of this study was to identify a mechanism related to miRNA pathway which plays a role in the anti-tumor effects of Diallyl disulfide. Alterations in miRNA expression were observed in Diallyl disulfide-treated MGC-803 cells, including up-regulation of miR-200b and miR-22 expression. Furthermore, Wnt-1 was identified as a target of both miR-200b and miR-22. MiR-200b and miR-22 not only synergistically inhibited gastric cancer growth, but also enhanced the antitumor effect of Diallyl disulfide both in vitro and in vivo. It indicated that miR-200b and miR-22 may serve as potential gene therapy and enhance Diallyl disulfide antitumor effects.
本研究旨在鉴定与 miRNA 通路相关的机制，该机制在二烯丙基二硫醚的抗肿瘤作用中发挥作用。在二烯丙基二硫醚处理的 MGC-803 细胞中观察到 miRNA 表达的改变，包括 miR-200b 和 miR-22 的表达上调。此外，Wnt-1 被鉴定为 miR-200b 和 miR-22 的共同靶标。miR-200b 和 miR-22 不仅协同抑制胃癌生长，而且在体外和体内增强了二烯丙基二硫醚的抗肿瘤作用。这表明 miR-200b 和 miR-22 可作为潜在的基因治疗方法，并增强二烯丙基二硫醚的抗肿瘤作用。
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