Department of Otolaryngology/Head and Neck Surgery, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan.
Otolaryngol Head Neck Surg. 2013 Oct;149(4):603-7. doi: 10.1177/0194599813496969. Epub 2013 Jul 12.
Following human papilloma virus (HPV) infection, recurrent respiratory papillomatosis (RRP) develops secondary to dysfunction of innate and adaptive immune responses. Diabetes mellitus (DM) is a common medical disorder; these patients are considered to be relatively immunocompromised. It is hypothesized that comorbid DM occurs more frequently than expected in a cohort of adult RRP patients and that RRP patients with DM have more severe disease than those without DM.
Retrospective cohort study.
Tertiary care laryngology practice, 5-year period.
Adult-onset RRP patients from 2007 to 2012 at the University of Washington were reviewed. The gender, age of onset of RRP, number of interventions, pathology, presence or absence of DM, and calculated anatomic Derkay severity score were recorded.
Eighty-four adult RRP patients were characterized; 64 male (76%) and 20 female (24%). Six of 84 patients (7.1%) had DM; this prevalence was not higher than an age-matched general population. The number of interventions required for disease control did not significantly differ (P = .13) between adult RRP patients with DM (avg 2.6/yr, median 2.3/year) and those without DM (avg 1.9/yr, median 1.3/yr). There was no significant difference in anatomic Derkay score at the time of intervention (P = .26) or presence of dysplasia in biopsy specimens (P = .49) between RRP patients with and without DM.
In this large series of adult RRP patients, DM does not appear to have a higher prevalence than that seen in age-matched controls, nor do RRP patients with DM appear to have more severe disease.
人乳头瘤病毒（HPV）感染后，复发性呼吸道乳头瘤病（RRP）继发于固有和适应性免疫反应功能障碍。糖尿病（DM）是一种常见的医学疾病；这些患者被认为相对免疫功能低下。据推测，在一组成年 RRP 患者中，合并 DM 的发病率高于预期，并且患有 DM 的 RRP 患者的疾病比没有 DM 的患者更严重。
回顾性队列研究。
华盛顿大学的三级护理喉科实践，为期 5 年。
回顾了 2007 年至 2012 年在华盛顿大学就诊的成年 RRP 患者。记录了性别、RRP 发病年龄、干预次数、病理学、是否存在 DM 以及计算的解剖学 Derkay 严重程度评分。
对 84 名成年 RRP 患者进行了特征描述；64 名男性（76%）和 20 名女性（24%）。84 名患者中有 6 名（7.1%）患有 DM；这一患病率并不高于同龄的一般人群。需要控制疾病的干预次数没有显著差异（P =.13），DM 成年 RRP 患者（平均 2.6/年，中位数 2.3/年）与无 DM 患者（平均 1.9/年，中位数 1.3/年）。在干预时的解剖学 Derkay 评分（P =.26）或活检标本中存在发育不良（P =.49）方面，RRP 患者中存在 DM 与无 DM 之间没有显著差异。
在这项大型成年 RRP 患者系列研究中，DM 的患病率似乎并不高于年龄匹配的对照组，并且患有 DM 的 RRP 患者的疾病似乎也不那么严重。
