在哥伦比亚，复发性呼吸道乳头瘤病（RRP）中人类乳头瘤病毒基因型的检测。
Human papillomavirus genotype detection in recurrent respiratory papillomatosis (RRP) in Colombia.
机构信息
Infection and Cancer Group, School of Medicine, University of Antioquia, Medellin, Colombia.
出版信息
Head Neck. 2013 Feb;35(2):229-34. doi: 10.1002/hed.22953. Epub 2012 Feb 24.
BACKGROUND
Knowledge on human papillomavirus (HPV) genotype distribution in recurrent respiratory papillomatosis (RRP) is essential to assess the impact of HPV vaccine. It is provided information for Colombia.
METHODS
In all, 189 RRP primary cases diagnosed between 1985 and 2009 were identified from 5 pathology laboratories of Cali and Medellin, Colombia. HPV DNA testing in 129 cases that fulfilled inclusion criteria (available paraffin blocks, amplifiable DNA, and confirmed histologic diagnosis of RRP) was performed by the SPF-10/LiPA25 assay (version 1).
RESULTS
Of all cases 36.1% were juvenile (<12 years old) and a majority of adults were males (p = .09); 95% of cases were HPV positive. HPV 6, 11, and 16 contributed to 69%, 27.1%, and 7.8% of all HPV positive cases. Twelve cases (9.3%) showed multiple infections; 8 of these were HPV 6 or 11 positive.
CONCLUSIONS
HPV prophylactic vaccine including HPV 6 and 11 may have a major impact against RRP.
背景
了解复发性呼吸道乳头瘤病（RRP）中人类乳头瘤病毒（HPV）基因型的分布对于评估 HPV 疫苗的影响至关重要。本文为哥伦比亚提供了相关信息。
方法
在哥伦比亚卡利和麦德林的 5 个病理实验室中，共发现了 189 例 RRP 初诊病例，这些病例均来自于 1985 年至 2009 年期间。通过 SPF-10/LiPA25 检测法（版本 1）对符合纳入标准（有可供检测的石蜡块、可扩增的 DNA 和经组织学证实的 RRP 诊断）的 129 例病例进行了 HPV DNA 检测。
结果
所有病例中，36.1%为青少年（<12 岁），大多数成年患者为男性（p=0.09）；95%的病例 HPV 呈阳性。HPV 6、11 和 16 分别占所有 HPV 阳性病例的 69%、27.1%和 7.8%。12 例（9.3%）表现为多重感染，其中 8 例为 HPV 6 或 11 阳性。
结论
包括 HPV 6 和 11 在内的 HPV 预防性疫苗可能对 RRP 有重大影响。
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