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本文引用的文献

1
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.中效非去极化神经肌肉阻滞剂与术后呼吸并发症风险:前瞻性倾向评分匹配队列研究。
BMJ. 2012 Oct 15;345:e6329. doi: 10.1136/bmj.e6329.
2
What is the predictor of prolonged operative time during laparoscopic radical prostatectomy?腹腔镜根治性前列腺切除术术中手术时间延长的预测因素是什么?
Int J Urol. 2013 Mar;20(3):330-6. doi: 10.1111/j.1442-2042.2012.03185.x. Epub 2012 Oct 10.
3
Does intraabdominal pressure affect development of subcutaneous emphysema at gynecologic laparoscopy?腹腔内压是否会影响妇科腹腔镜手术中皮下气肿的发生?
J Minim Invasive Gynecol. 2011 Nov-Dec;18(6):761-5. doi: 10.1016/j.jmig.2011.08.006. Epub 2011 Sep 21.
4
Secrets of safe laparoscopic surgery: Anaesthetic and surgical considerations.安全腹腔镜手术的秘诀:麻醉与手术考量
J Minim Access Surg. 2010 Oct;6(4):91-4. doi: 10.4103/0972-9941.72593.
5
Shoulder pain following laparoscopic cholecystectomy: factors affecting the incidence and severity.腹腔镜胆囊切除术后的肩部疼痛:影响发生率和严重程度的因素
J Laparoendosc Adv Surg Tech A. 2010 Oct;20(8):677-82. doi: 10.1089/lap.2010.0112.
6
Residual paralysis after emergence from anesthesia.麻醉苏醒后的残余麻痹。
Anesthesiology. 2010 Apr;112(4):1013-22. doi: 10.1097/ALN.0b013e3181cded07.
7
A prospective randomized comparison of vaginal hysterectomy, laparoscopically assisted vaginal hysterectomy, and total laparoscopic hysterectomy in women with benign uterine disease.前瞻性随机比较经阴道子宫切除术、腹腔镜辅助经阴道子宫切除术和全腹腔镜子宫切除术治疗良性子宫疾病的女性。
Eur J Obstet Gynecol Reprod Biol. 2010 Feb;148(2):172-6. doi: 10.1016/j.ejogrb.2009.10.019. Epub 2009 Nov 18.
8
Sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade.舒更葡糖钠,一种用于预防术后残余神经肌肉阻滞的选择性逆转药物。
Cochrane Database Syst Rev. 2009 Oct 7(4):CD007362. doi: 10.1002/14651858.CD007362.pub2.
9
Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine.舒更葡糖钠逆转罗库溴铵所致深度神经肌肉阻滞的效果:与新斯的明的随机对照比较
Anesthesiology. 2008 Nov;109(5):816-24. doi: 10.1097/ALN.0b013e31818a3fee.
10
Low-pressure pneumoperitoneum versus standard pneumoperitoneum in laparoscopic cholecystectomy, a prospective randomized clinical trial.腹腔镜胆囊切除术中低压气腹与标准气腹的前瞻性随机临床试验
Surg Endosc. 2009 May;23(5):1044-7. doi: 10.1007/s00464-008-0119-2. Epub 2008 Sep 23.

深度神经肌肉阻滞会导致腹腔镜检查期间腹腔内体积增大。

Deep neuromuscular blockade leads to a larger intraabdominal volume during laparoscopy.

作者信息

Lindekaer Astrid Listov, Halvor Springborg Henrik, Istre Olav

机构信息

Department of Anesthesiology, Aleris-Hamlet Hospitals, Soeborg, Denmark.

出版信息

J Vis Exp. 2013 Jun 25(76):50045. doi: 10.3791/50045.

DOI:10.3791/50045
PMID:23851450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3728987/
Abstract

Shoulder pain is a commonly reported symptom following laparoscopic procedures such as myomectomy or hysterectomy, and recent studies have shown that lowering the insufflation pressure during surgery may reduce the risk of post-operative pain. In this pilot study, a method is presented for measuring the intra-abdominal space available to the surgeon during laproscopy, in order to examine whether the relaxation produced by deep neuromuscular blockade can increase the working surgical space sufficiently to permit a reduction in the CO2 insufflation pressure. Using the laproscopic grasper, the distance from the promontory to the skin is measured at two different insufflation pressures: 8 mm Hg and 12 mm Hg. After the initial measurements, a neuromuscular blocking agent (rocuronium) is administered to the patient and the intra-abdominal volume is measured again. Pilot data collected from 15 patients shows that the intra-abdominal space at 8 mm Hg with blockade is comparable to the intra-abdominal space measured at 12 mm Hg without blockade. The impact of neuromuscular blockade was not correlated with patient height, weight, BMI, and age. Thus, using neuromuscular blockade to maintain a steady volume while reducing insufflation pressure may produce improved patient outcomes.

摘要

肩部疼痛是子宫肌瘤切除术或子宫切除术等腹腔镜手术后常见的症状,最近的研究表明,在手术过程中降低气腹压力可能会降低术后疼痛的风险。在这项初步研究中,提出了一种在腹腔镜检查期间测量外科医生可用腹腔空间的方法,以检查深度神经肌肉阻滞产生的松弛是否能充分增加手术工作空间,从而允许降低二氧化碳气腹压力。使用腹腔镜抓钳,在两种不同的气腹压力下测量从岬部到皮肤的距离:8毫米汞柱和12毫米汞柱。在初始测量后,给患者使用神经肌肉阻滞剂(罗库溴铵),然后再次测量腹腔容积。从15名患者收集的初步数据表明,在8毫米汞柱气腹压力下使用阻滞剂时的腹腔空间与在12毫米汞柱气腹压力下未使用阻滞剂时测量的腹腔空间相当。神经肌肉阻滞的影响与患者的身高、体重、体重指数和年龄无关。因此,在降低气腹压力的同时使用神经肌肉阻滞来维持稳定的容积可能会改善患者的预后。