College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
Chem Commun (Camb). 2013 Sep 4;49(68):7492-4. doi: 10.1039/c3cc43741h.
A tunable and highly regio- and diastereoselective addition of acyclic silyl dienolates 2 to several α-fluoroalkyl sulfinylimines 1 was developed. By appropriate choice of the Lewis acid catalyst, two new chiral α-fluoroalkyl amines 3 and 4 were obtained in good yields and excellent diastereoselectivities (up to >99 : 1 dr), respectively.
发展了一种非环硅烯醇盐 2 与几种 α-氟烷基亚磺酰亚胺 1 的可调、高区域和立体选择性加成反应。通过适当选择路易斯酸催化剂，分别以良好的收率和优异的立体选择性（高达 >99:1 dr）得到了两个新的手性 α-氟烷基胺 3 和 4。
