路易斯酸催化的通过硅烯醇酯与氟化亚磺酰亚胺的不对称加成反应构建手性α-氟烷基胺的区域选择性合成方法。
Lewis acid-catalyzed regioselective synthesis of chiral α-fluoroalkyl amines via asymmetric addition of silyl dienolates to fluorinated sulfinylimines.
机构信息
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
出版信息
Chem Commun (Camb). 2013 Sep 4;49(68):7492-4. doi: 10.1039/c3cc43741h.
PMID:23851464
Abstract
A tunable and highly regio- and diastereoselective addition of acyclic silyl dienolates 2 to several α-fluoroalkyl sulfinylimines 1 was developed. By appropriate choice of the Lewis acid catalyst, two new chiral α-fluoroalkyl amines 3 and 4 were obtained in good yields and excellent diastereoselectivities (up to >99 : 1 dr), respectively.
摘要
发展了一种非环硅烯醇盐 2 与几种 α-氟烷基亚磺酰亚胺 1 的可调、高区域和立体选择性加成反应。通过适当选择路易斯酸催化剂，分别以良好的收率和优异的立体选择性（高达 >99:1 dr）得到了两个新的手性 α-氟烷基胺 3 和 4。
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