Gerbes A L, Xie Y N, Mezger J, Jüngst D
Department of Medicine II, University of Munich, Federal Republic of Germany.
Liver. 1990 Jun;10(3):152-7. doi: 10.1111/j.1600-0676.1990.tb00451.x.
Ascitic fluid concentrations of fibronectin, cholesterol and protein were determined in 95 patients: 38 with cirrhosis of the liver, 10 with miscellaneous nonmalignant diseases, 43 with peritoneal carcinomatosis and 4 with liver metastases or hepatocellular carcinoma. Fibronectin, cholesterol and protein at discrimination values of 7.5 mg/100 ml, 45 mg/100 ml and 3.0 g/100 ml, respectively, separated patients with peritoneal carcinomatosis from patients with cirrhosis with an efficiency of 94%, 90% and 85%, respectively. Thus, ascitic fluid determinations of fibronectin and cholesterol offer good discrimination of cirrhotic ascites from ascites related to peritoneal carcinomatosis, superior to the conventional protein determination. However, the failure of all parameters to distinguish ascites caused by miscellaneous nonmalignant diseases from malignancy-related ascites underscores the importance of highly specific methods to confirm a suspected diagnosis of malignancy-related ascites.
对95例患者的腹水进行了纤维连接蛋白、胆固醇和蛋白质浓度测定，其中38例为肝硬化患者，10例为其他非恶性疾病患者，43例为腹膜癌患者，4例为肝转移或肝细胞癌患者。纤维连接蛋白、胆固醇和蛋白质的鉴别值分别为7.5mg/100ml、45mg/100ml和3.0g/100ml，将腹膜癌患者与肝硬化患者区分开来的效率分别为94%、90%和85%。因此，腹水纤维连接蛋白和胆固醇的测定能很好地区分肝硬化腹水和腹膜癌相关腹水，优于传统的蛋白质测定。然而，所有参数均无法区分其他非恶性疾病引起的腹水与恶性肿瘤相关腹水，这突出了采用高度特异性方法来确诊疑似恶性肿瘤相关腹水的重要性。
