Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, Seoul, 150-034, Korea,
Jpn J Ophthalmol. 2013 Sep;57(5):463-70. doi: 10.1007/s10384-013-0263-7. Epub 2013 Jul 13.
To evaluate the effect of myopia and age on temporal optic disc margin anatomy within the parapapillary atrophy (PPA) area by use of spectral-domain optical coherence tomography (OCT).
Fifty young myopic eyes with PPA (myopic PPA group), 50 aged non-myopic eyes with PPA (aged PPA group), and 50 young non-myopic eyes without PPA (control group) were enrolled. High-definition OCT scanning was used to obtain horizontal cross-sectional optic nerve head (ONH) images. By use of these OCT scans we investigated three temporal optic disc margin structures: the configuration of the border tissue of Elschnig; the cross-sectional ONH structure coinciding with the clinically detected optic disc margin; and the integrity of the retinal layers within the PPA area.
The distribution of the configuration of the border tissue of Elschnig and the cross-sectional ONH structure coinciding with the clinically detected optic disc margin of the myopic PPA group differed significantly from those of the control group (P < 0.01) whereas those of the aged PPA group did not (P > 0.05). Other than the photoreceptor layer, the retinal layers within the PPA area were more commonly impaired in the myopic PPA group than in the aged PPA group (P < 0.001).
Myopia and aging led to different structural changes in temporal optic disc margin anatomy within the PPA area. This finding implies that different mechanisms may underlie myopic and age-related PPA development.
通过频域光相干断层扫描（OCT）评估近视和年龄对青光眼旁区（PPA）内视盘边缘组织解剖结构的影响。
纳入 50 例近视伴 PPA（近视性 PPA 组）、50 例年龄相关性非近视伴 PPA（年龄相关性 PPA 组）和 50 例非近视非 PPA（对照组）的年轻患者。采用高清 OCT 扫描获取水平视神经乳头（ONH）横断面图像。通过这些 OCT 扫描，我们研究了三个颞侧视盘边缘结构：Elschnig 边界组织的形态；与临床检测的视盘边缘相吻合的 ONH 结构的横截面；以及 PPA 区域内视网膜层的完整性。
近视性 PPA 组的 Elschnig 边界组织形态和与临床检测的视盘边缘相吻合的 ONH 结构的分布与对照组有显著差异（P<0.01），而年龄相关性 PPA 组则没有差异（P>0.05）。除了光感受器层外，近视性 PPA 组 PPA 区内的视网膜层更常受损（P<0.001）。
近视和衰老导致 PPA 区颞侧视盘边缘组织解剖结构发生不同的结构变化。这一发现表明，近视和年龄相关性 PPA 的发展可能存在不同的机制。
