Am J Epidemiol. 2013 Sep 15;178(6):974-83. doi: 10.1093/aje/kwt054. Epub 2013 Jul 12.
Estimates of life expectancy are useful in assessing whether different prevention strategies are appropriate in different populations. We developed sex-specific Cox proportional-hazard models that use Medicare claims data to predict life expectancy and risk of death at up to 10 years for older adults. We identified a cohort of Medicare beneficiaries 66-90 years of age from the 5% Medicare claims data in 2000 (n = 1,137,311) and tracked each subject's vital status until December 31, 2009. Subjects were split randomly into training and validation samples. Models were developed from the training sample and validated by comparison of predicted to actual survival in the validation sample. The C statistics for the models including predictors of age and Elixhauser comorbidities were 0.76-0.79 for men and women for prediction of death at the 1-, 5-, 7-, and 10-year follow-up periods. More than 80% of subjects with <25% risk of death at 5, 7, and 10 years survived longer than the chosen cutoff years. More than 80% of subjects with ≥75% risk of death at 5, 7, and 10 years died by those cutoff years. The models overestimated the risk of death at 1 year for the high-risk groups. Sex-specific models that use age and Elixhauser comorbidities can accurately predict patient life expectancy and risk of death at 5-10 years.
预期寿命的估计对于评估不同的预防策略在不同人群中的适用性是有用的。我们开发了特定于性别的 Cox 比例风险模型,该模型使用医疗保险索赔数据来预测 66-90 岁的老年人在最多 10 年内的预期寿命和死亡风险。我们从 2000 年的 5%医疗保险索赔数据中确定了一组 Medicare 受益人的队列(n=1,137,311),并跟踪每个受试者的生存状态,直到 2009 年 12 月 31 日。受试者被随机分为训练样本和验证样本。模型是从训练样本中开发的,并通过在验证样本中比较预测的与实际生存情况来验证。包括年龄和 Elixhauser 合并症预测因素的模型的 C 统计量在男性和女性中分别为 0.76-0.79,用于预测 1 年、5 年、7 年和 10 年随访期间的死亡。超过 80%的预期寿命为 5 年、7 年和 10 年的风险<25%的受试者比选择的截止年份存活的时间更长。超过 80%的预期寿命为 5 年、7 年和 10 年的风险≥75%的受试者在截止年份之前死亡。这些模型高估了高风险组在 1 年内的死亡风险。使用年龄和 Elixhauser 合并症的特定于性别的模型可以准确预测患者的预期寿命和 5-10 年内的死亡风险。