Department of Rheumatology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, 100020, China.
Inflammation. 2013 Dec;36(6):1460-7. doi: 10.1007/s10753-013-9687-y.
Avastin is the monoclonal antibody for vascular endothelial growth factor (VEGF). This study aimed to investigate therapeutic effect of Avastin on type II collagen-induced arthritis. Type II chicken collagen was injected into the tails of Wistar rats, and 60 modeled female rats were randomly divided into three groups (n = 20): Avastin group, Etanercept group, and control group. Arthritis index and joint pad thickness were scored, and the pathology of back metapedes was analyzed. The results showed that compared to control group, the arthritis index, target-to-non-target ratio, synovial pathological injury index, serum levels of VEGF and tumor necrosis factor alpha, and VEGF staining were decreased significantly 14 days after Avastin or Etanercept treatment, but there were no significant differences between Avastin group and Etanercept group. These data provide evidence that Avastin exhibits similar effects to Etanercept to relieve rheumatoid arthritis in rat model and suggest that Avastin is a promising therapeutic agent for rheumatoid arthritis.
贝伐珠单抗是一种针对血管内皮生长因子（VEGF）的单克隆抗体。本研究旨在探讨贝伐珠单抗对Ⅱ型胶原诱导性关节炎的治疗作用。将Ⅱ型鸡胶原注入 Wistar 大鼠尾部，构建关节炎模型，将 60 只雌性大鼠随机分为三组（n=20）：贝伐珠单抗组、依那西普组和对照组。分别对关节炎指数和关节垫厚度进行评分，并分析后肢病理变化。结果显示，与对照组相比，贝伐珠单抗或依那西普治疗 14 天后，关节炎指数、靶关节与非靶关节比值、滑膜病理损伤指数、血清 VEGF 和肿瘤坏死因子-α水平以及 VEGF 染色均明显降低，但贝伐珠单抗组与依那西普组之间差异无统计学意义。这些数据为贝伐珠单抗具有与依那西普相似的缓解类风湿关节炎作用的效果提供了证据，提示贝伐珠单抗可能是一种有前途的类风湿关节炎治疗药物。
