Sener Ismail, Bereket Cihan, Kosker Huseyin, Turer Akif, Tek Mustafa, Kaplan Suleyman
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey.
J Craniofac Surg. 2013 Jul;24(4):1221-4. doi: 10.1097/SCS.0b013e3182997816.
The aim of this study was to evaluate the effect of zoledronic acid (ZA) in the ovariectomized rat on mandibular fracture. Corpus osteotomies were performed on the mandible of ovariectomized rats. Miniplates were placed on these rats, which were randomly divided into 4 groups. After 7 days, groups 3 and 4 were injected with 0.1 mg/kg ZA. Groups 1 and 2 were control groups, so they were injected 0.1 mg/kg saline solution. Animals in groups 1 and 3 were killed at 4 weeks, whereas groups 2 and 4 were killed 8 weeks after operation. The new bone volume of the fracture gap was examined stereologically. Although the difference was not statistically significant compared with the other groups (groups 1 and 3), more bone formation was found in ZA-treated groups (groups 2 and 4) (P < 0.05).
本研究的目的是评估唑来膦酸（ZA）对去卵巢大鼠下颌骨骨折的影响。对去卵巢大鼠的下颌骨进行体部截骨术。在这些大鼠身上放置微型钢板，将其随机分为4组。7天后，第3组和第4组注射0.1mg/kg ZA。第1组和第2组为对照组，因此注射0.1mg/kg盐溶液。第1组和第3组的动物在4周时处死，而第2组和第4组在术后8周处死。采用体视学方法检查骨折间隙的新骨体积。尽管与其他组（第1组和第3组）相比差异无统计学意义，但在ZA治疗组（第2组和第4组）中发现更多的骨形成（P<0.05）。
