Pampu A Alper, Dolanmaz Doğan, Tüz Hakan H, Karabacakoglu Aydin
Department of Oral and Maxillofacial Surgery, Selcuk University, Faculty of Dentistry, Konya, Turkey.
J Oral Maxillofac Surg. 2006 Aug;64(8):1232-6. doi: 10.1016/j.joms.2006.04.038.
The aim of this study was to evaluate the effects of systemically administered zoledronic acid (ZA) on the bone mineral density (BMD) and bone mineral content (BMC) at mandibular distraction sites in rabbits.
Eighteen New Zealand white rabbits were randomly divided into 2 groups. Bone lengthening was performed in the left portion of the mandible through distraction osteogenesis at a rate of 0.5 mm every 12 hours for 5 days. While the experimental group rabbits were administered intravenous 0.1 mg/kg ZA, control group rabbits were given only saline infusion during operation. All animals were sacrificed at the end of the consolidation period of 28 days. The mandibles of all animals were removed and both the anterior and posterior pin regions of the regenerate and regenerate region were evaluated by dual energy x-ray absorptiometry (DEXA). BMD and BMC data were statistically analyzed.
Except for 1 rabbit from the experimental group that had an infection at the external pin region, all animals showed complete clinical healing. When the values in the group receiving ZA were compared with those of the control group, it was observed that the BMD values of the anterior pin region of regenerate, regenerate region, and posterior pin region increased by 23%, 20%, and 31%, respectively; and BMC values increased by 22%, 24%, and 32%, respectively. When data of these regions were compared, both BMD and BMC were found statistically different in all regions (P < .05).
Results of this study showed that ZA had positive effects on new bone formation at and around the distraction gaps of the lengthened rabbit mandibles by distraction osteogenesis.
本研究旨在评估全身应用唑来膦酸（ZA）对兔下颌骨牵张部位骨密度（BMD）和骨矿物质含量（BMC）的影响。
18只新西兰白兔随机分为2组。通过牵张成骨在下颌骨左侧进行骨延长，以每12小时0.5mm的速率持续5天。实验组兔静脉注射0.1mg/kg ZA，对照组兔在手术期间仅输注生理盐水。所有动物在28天的巩固期结束时处死。取出所有动物的下颌骨，通过双能X线吸收法（DEXA）评估再生骨的前后针道区域和再生区域。对BMD和BMC数据进行统计学分析。
除实验组1只兔在外部针道区域发生感染外，所有动物均实现临床完全愈合。将接受ZA组的值与对照组的值进行比较时，观察到再生骨前针道区域、再生区域和后针道区域的BMD值分别增加了23%、20%和31%；BMC值分别增加了22%、24%和32%。比较这些区域的数据时，发现所有区域的BMD和BMC在统计学上均有差异（P <.05）。
本研究结果表明，ZA对通过牵张成骨延长的兔下颌骨牵张间隙及其周围的新骨形成有积极作用。
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