Sakamoto Yoshiaki, Ochiai Hiroko, Ohsugi Ikuko, Inoue Yoshikazu, Yoshimura Yohko, Kishi Kazuo
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.
J Craniofac Surg. 2013 Jul;24(4):1447-50. doi: 10.1097/SCS.0b013e31829972de.
Some case reports described the usage of bone cement mixed with antibiotics. However, there are few studies that referred to experimental research of calcium phosphate cement with antibiotics. Thus, we mixed vancomycin and amikacin with bone cement in various concentrations and examined its characterization and antibacterial activity. As a result, 6.25 wt% over the concentration could not mix with cement. With an increase in the antibiotic content, the hardening time was prolonged and the compressive strength tended to decrease. In consistency, vancomycin mixed cement increased, whereas amikacin mixed cement decreased. The elution of antibiotics showed sustained release. In conclusion, the characteristics of the bone cement changed based on the amount of antibiotics added, and calcium phosphate cement is useful as a drug carrier.
一些病例报告描述了骨水泥与抗生素混合的用法。然而，很少有研究提及含抗生素的磷酸钙骨水泥的实验研究。因此，我们将万古霉素和丁胺卡那霉素以不同浓度与骨水泥混合，并检测其特性和抗菌活性。结果，超过6.25 wt%的浓度无法与骨水泥混合。随着抗生素含量的增加，固化时间延长，抗压强度趋于降低。在稠度方面，万古霉素混合骨水泥增加，而丁胺卡那霉素混合骨水泥降低。抗生素的洗脱呈持续释放。总之，骨水泥的特性随添加抗生素的量而改变，磷酸钙骨水泥作为药物载体是有用的。
