Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Ther Drug Monit. 2013 Aug;35(4):417-9. doi: 10.1097/FTD.0b013e31828faa35.
Acyclovir-induced neuropsychiatric symptoms (AINSs) may resemble several diseases of the central nervous system. Laboratory testing of acyclovir may be critical in supporting the diagnosis of AINSs when there is doubt. We present a case of suspected herpes encephalitis in which the diagnosis of AINSs was supported by therapeutic drug monitoring of plasma and cerebrospinal fluid concentrations of acyclovir and its main metabolite 9-carboxymethoxymethylguanine.
阿昔洛韦引起的神经精神症状（AINSs）可能类似于几种中枢神经系统疾病。当存在疑问时，对阿昔洛韦的实验室检测可能对支持 AINSs 的诊断至关重要。我们报告了一例疑似疱疹性脑炎的病例，其中通过对阿昔洛韦及其主要代谢物 9-羧基甲氧基甲基鸟嘌呤的血浆和脑脊液浓度进行治疗药物监测，支持了 AINSs 的诊断。
