Université de Strasbourg, Laboratoire de Chimie Moléculaire, CNRS UMR 7509, Ecole Européenne de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67087, Strasbourg, France.
Org Biomol Chem. 2013 Sep 7;11(33):5393-8. doi: 10.1039/c3ob40997j.
Although sulfur dioxide (SO2) has been used as a reagent for organic chemistry for more than one hundred years, being endowed with quite a distinct and varied reactivity profile, which allows the synthesis of a large range of compounds, its notorious toxicity as well as its gaseous state have impeded its frequent utilization by chemists. We summarize recent studies in this emerging area aimed at stimulating its utilization in organic (including organometallic) chemistry thanks to the development of innocuous, bench-stable reliable SO2 donors. Proof-of-concept experiments have also been recently performed in biology with the design of organic SO2 donors having controlled release profiles under physiological conditions, either active against mycobacteria or used for clarifying the role of endogenously produced SO2 in living cells.
尽管二氧化硫（SO2）作为一种有机化学试剂已经有一百多年的历史了，具有相当独特和多样化的反应性，允许合成各种化合物，但由于其毒性和气体状态，化学家们很少使用它。我们总结了最近在这一新兴领域的研究，旨在通过开发无害、稳定可靠的 SO2 供体来刺激其在有机（包括有机金属）化学中的应用。最近还在生物学中进行了概念验证实验，设计了具有生理条件下可控释放特性的有机 SO2 供体，这些供体要么对抗分枝杆菌有效，要么用于阐明内源性产生的 SO2 在活细胞中的作用。
