受改良朱利亚烯烃化反应启发的酯酶敏感型二氧化硫前药。
Esterase-sensitive sulfur dioxide prodrugs inspired by modified Julia olefination.
作者信息
Wang Wenyi, Wang Binghe
机构信息
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303, USA.
出版信息
Chem Commun (Camb). 2017 Sep 12;53(73):10124-10127. doi: 10.1039/c7cc05392d.
PMID:28840924
Abstract
Sulfur dioxide (SO) is an endogenously produced gaseous molecule, and is emerging as a potential gasotransmitter. Herein, we describe the first series of esterase-sensitive prodrugs inspired by modified Julia olefination as SO donors.
摘要
二氧化硫（SO）是一种内源性产生的气体分子，正逐渐成为一种潜在的气体递质。在此，我们描述了首个受改良朱利亚烯烃化反应启发而设计的、作为SO供体的酯酶敏感前药系列。
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