Bora Prerona, Chauhan Preeti, Pardeshi Kundansingh A, Chakrapani Harinath
Department of Chemistry, Indian Institute of Science Education and Research Pune Pune 411 008 Maharashtra India
RSC Adv. 2018 Jul 31;8(48):27359-27374. doi: 10.1039/c8ra03658f. eCollection 2018 Jul 30.
Sulfur metabolism is integral to cellular growth and survival. The presence of a wide range of oxidation states of sulfur in biology coupled with its unique reactivity are some key features of the biology of this element. In particular, nearly all oxidation states of sulfur not only occur but are also inter-convertible. In order to study the chemical biology of reactive sulfur species, tools to reliably detect as well as generate these species within cells are necessary. Herein, an overview of strategies to generate certain reactive sulfur species is presented. The donors of reactive sulfur species have been organized based on their oxidation states. These interesting small molecules have helped lay a strong foundation to study the biology of reactive sulfur species and some may have therapeutic applications in the future as well.
硫代谢对于细胞生长和存活至关重要。生物学中硫存在多种氧化态，且具有独特的反应活性，这些是该元素生物学特性的一些关键特征。特别是，几乎所有硫的氧化态不仅存在，而且还可相互转化。为了研究活性硫物种的化学生物学，需要能够在细胞内可靠检测和生成这些物种的工具。本文概述了生成某些活性硫物种的策略。活性硫物种的供体已根据其氧化态进行了分类。这些有趣的小分子为研究活性硫物种的生物学奠定了坚实基础，并且其中一些在未来可能也具有治疗应用价值。
