Laboratoire de Physique de la Matière Condensée-Ecole Polytechnique-CNRS, UMR 7643, 91128 Palaiseau Cedex, France.
Nanoscale. 2013 Sep 21;5(18):8466-71. doi: 10.1039/c3nr01251d.
We report an efficient colloidal synthesis of KTiOPO4 (KTP) nanocrystals with excellent crystallinity and the direct observation of optical second-harmonic generation (SHG) from discrete KTP nanocrystals in neurons cultured from mammalian brain cortex. Direct internalization and monitoring of these nanoparticles was successfully achieved without limitations from cytotoxicity, bleaching and blinking emission.
我们报告了一种高效的胶体合成方法，用于制备具有优异结晶度的 KTiOPO4（KTP）纳米晶体，并直接观察到来自哺乳动物大脑皮层培养神经元中离散 KTP 纳米晶体的光学二次谐波产生（SHG）。这些纳米粒子可以成功地进行直接内化和监测，而不会受到细胞毒性、漂白和闪烁发射的限制。
