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可补充的树枝状聚合物-纳米粒子杂化膜用于治疗药物的持续释放。

Replenishable dendrimer-nanoparticle hybrid membranes for sustained release of therapeutics.

机构信息

Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003, USA.

出版信息

Nanoscale. 2013 Sep 7;5(17):7805-8. doi: 10.1039/c3nr02049e.

DOI:10.1039/c3nr02049e
PMID:23852409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3754779/
Abstract

We report a versatile hybrid membrane for sustained release therapeutic delivery systems. Chemically-directed assembly of a hybrid membrane of nanoparticles and dendrimers was integrated with a fluidic delivery device and a refillable drug reservoir, providing continuous sustained release.

摘要

我们报告了一种多功能混合膜，用于持续释放治疗输送系统。通过化学导向组装，将纳米粒子和树枝状大分子的混合膜与流体输送装置和可再填充药物储库集成在一起，提供持续的持续释放。

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本文引用的文献

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Drug Delivery: Enabling Technology for Drug Discovery and Development. iPRECIO Micro Infusion Pump: Programmable, Refillable, and Implantable.药物输送：药物发现和开发的实现技术。iPRECIO 微输注泵：可编程、可再填充和可植入。
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Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release.磁触发纳米复合膜：一种用于触发药物释放的多功能平台。
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Electrically actuatable smart nanoporous membrane for pulsatile drug release.电致动智能纳米多孔膜用于脉冲式药物释放。
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Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release.用于肿瘤渗透的磁性靶向纳米胶囊及其按需远程开关的药物释放
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Knowledge-based approach towards hydrolytic degradation of polymer-based biomaterials.基于知识的方法研究聚合物基生物材料的水解降解。
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Release of DNA from polyelectrolyte multilayers fabricated using 'charge-shifting' cationic polymers: tunable temporal control and sequential, multi-agent release.利用“电荷转移”阳离子聚合物制备的聚电解质多层膜中 DNA 的释放：可调时控制和顺序、多试剂释放。
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Multimodal drug delivery using gold nanoparticles.使用金纳米粒子的多模式药物递送。
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