National Creative Research Initiative Center for Block Copolymer Self-Assembly, Department of Chemical Engineering, Pohang University of Science and Technology , Kyungbuk 790-784, Korea.
Nano Lett. 2011 Mar 9;11(3):1284-8. doi: 10.1021/nl104329y. Epub 2011 Jan 31.
We report on the fabrication of electrically responsive nanoporous membrane based on polypyrrole doped with dodecylbenzenesulfonate anion (PPy/DBS) that was electropolymerized on the upper part of anodized aluminum oxide membrane. The membrane has regular pore size and very high pore density. Utilizing a large volume change of PPy/DBS depending on electrochemical state, the pore size was acutated electrically. The actuation of the pores was experimentally confirmed by in situ atomic force microscopy and in situ flux measurement. We also demonstrated successfully pulsatile (or on-demand) drug release by using fluorescently labeled protein as a model drug. Because of a fast switching time (less than 10 s) and high flux of the drugs, this membrane could be used for emergency therapy of angina pectoris and migraine, which requires acute and on-demand drug delivery, and hormone-related disease and metabolic syndrome.
我们报告了一种基于掺杂有十二烷基苯磺酸盐阴离子的聚吡咯（PPy/DBS）的电响应纳米多孔膜的制备，该膜是在阳极氧化铝膜的上部电聚合而成的。该膜具有规则的孔径和非常高的孔径密度。利用 PPy/DBS 的电化学状态依赖性的大体积变化，通过电刺激来调节孔径。通过原位原子力显微镜和原位通量测量实验证实了这种调节。我们还成功地利用荧光标记的蛋白质作为模型药物展示了脉冲式（或按需）药物释放。由于快速的开关时间（小于 10 秒）和高药物通量，这种膜可用于心绞痛和偏头痛的紧急治疗，这些疾病需要急性和按需药物输送，以及与激素相关的疾病和代谢综合征。
